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- W2045494764 abstract "Anti-neutrophil cytoplasmic antibodies (ANCAs) of the immunoglobulin (Ig) G isotype are associated with rapidly progressive glomerulonephritis. These have been detected rarely in patients with Henoch-Schonlein purpura (HSP) and have only been previously reported once in a patient with IgA nephropathy (IgAN). In contrast, IgA-ANCAs have been detected in patients with HSP or IgAN, although further verification of this finding by various investigators has yielded conflicting results. We report a case of biopsy-proven IgAN in which the patient developed a rapidly progressive glomerulonephritis and was determined to have ANCAs of both IgA and IgG isotypes. This report suggests an association between fulminant IgAN and ANCA-associated disease and that ANCAs may be underdetected in children with previously diagnosed IgAN. Identification of these antibodies may guide further management of these patients. (Am J Kidney Dis 1998 Feb;31(2):341-4)" @default.
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- W2045494764 date "1998-02-01" @default.
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- W2045494764 title "IgG antineutrophil cytoplasmic antibodies in IgA nephropathy: A clinical variant?" @default.
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- W2045494764 doi "https://doi.org/10.1053/ajkd.1998.v31.pm9469508" @default.
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