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• W2045494953 startingPage "617" @default.
• W2045494953 abstract "Studies of gene expression following fear conditioning have demonstrated that the inducible transcription factor, egr-1, is increased in the lateral nucleus of the amygdala shortly following fear conditioning. These studies suggest that egr-1 and its protein product Egr-1 in the amygdala are important for learning and memory of fear. To directly test this hypothesis, an egr-1 antisense oligodeoxynucleotide (antisense-ODN) was injected bilaterally into the amygdala prior to contextual fear conditioning. The antisense-ODN reduced Egr-1 protein in the amygdala and interfered with fear conditioning. A 250-pmole dose produced an 11% decrease in Egr-1 protein and reduced long-term memory of fear as measured by freezing in a retention test 24 h after conditioning, but left shock-induced freezing intact. A larger 500-pmole dose produced a 25% reduction in Egr-1 protein and significantly decreased both freezing immediately following conditioning and freezing in the retention test. A nonsense-ODN had no effect on postshock or retention test freezing. In addition, 500 pmole of antisense-ODN infused prior to the retention test in previously trained rats did not reduce freezing, indicating that antisense-ODN did not suppress conditioned fear behavior. Finally, rats infused with 500 pmole of antisense-ODN displayed unconditioned fear to a predator odor, demonstrating that unconditioned freezing was unaffected by the antisense-ODN. The data indicate that the egr-1 antisense-ODN interferes with learning and memory processes of fear without affecting freezing behavior and suggests that the inducible transcription factor Egr-1 within the amygdala plays important functions in long-term learning and memory of fear." @default.
• W2045494953 created "2016-06-24" @default.
• W2045494953 creator A5015506484 @default.
• W2045494953 creator A5020678717 @default.
• W2045494953 creator A5026271123 @default.
• W2045494953 creator A5035112257 @default.
• W2045494953 date "2004-09-01" @default.
• W2045494953 modified "2023-10-18" @default.
• W2045494953 title "An <i>egr-1</i> (<i>zif268</i>) Antisense Oligodeoxynucleotide Infused Into the Amygdala Disrupts Fear Conditioning" @default.
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• W2045494953 doi "https://doi.org/10.1101/lm.73104" @default.
• W2045494953 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/523081" @default.
• W2045494953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15466317" @default.
• W2045494953 hasPublicationYear "2004" @default.
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