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- W2045495584 abstract "Rubratoxin B, a mycotoxin (R), was shown to be mutagenic and teratogenic. Male mice were treated with R, 0.75 or 1.5 mg/kg ip, for 5 days and then mated for 8 consecutive weeks with untreated virgin female mice. R reduced fecundity only at the higher dosage with no change in mating behavior. A dose-related increase in early fetal deaths was observed. Similarly, R induced a dose-related increase in resorption rate among pregnant females treated during gestational Days 8 throught 12. R also produced a significant decrease in fetal body weight and a significant incidence of fetal defects. Hydrogenation of R to saturate the lactone ring reduced the acute toxicity significantly. Hydrogenated R was not mutagenic at doses up to 10 times the mutagenic dose of R. Similarly, hydrogenated R had no effect on prenatal growth and development." @default.
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- W2045495584 date "1977-01-01" @default.
- W2045495584 modified "2023-10-14" @default.
- W2045495584 title "Prenatal toxicity of rubratoxin B and its hydrogenated analog" @default.
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- W2045495584 doi "https://doi.org/10.1016/0041-008x(77)90172-7" @default.
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