FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045496528> ?p ?o ?g. }

• W2045496528 endingPage "899" @default.
• W2045496528 startingPage "889" @default.
• W2045496528 abstract "Histone acetylation regulates higher-order chromatin structure and function and is critical for the control of gene expression. Histone deacetylase inhibitors (HDACi) are currently un¬der investigation as novel cancer therapeutic drugs. Here, we show that female germ cells are extremely suscep¬tible to chromatin changes induced by HDACi. Our results indicate that exposure to trichostatin A (TSA) at nanomolar levels interferes with major chromatin remodeling events in the mammalian oocyte leading to chromosome instability. High resolution analysis of chromatin structure and live-cell imaging revealed a striking euchromatin decondensation associated with histone H4 hyperacetylation following exposure to 15 nM TSA in >90% of pre-ovulatory oocytes. Dynamic changes in large-scale chromatin structure were detected after 2 h of exposure and result in the formation of misaligned chromosomes in >75% (<I>P</I><0.05) of <I>in vitro</I> matured oocytes showing chromosome lagging as well as abnormal sister chromatid separation at anaphase I. Abnormal axial chromatid condensation during meiosis results in the formation of elongated chromosomes exhibiting hyperacetylation of histone H4 at lysine 5 and lysine 16 at interstitial chromosome segments, but not pericentric heterochro¬matin, while highly decondensed bivalents exhibit prominent histone H3 phosphorylation at centromeric domains. Notably, no changes were observed in the chromosomal localization of the condensin protein SMC4. These results indicate that HDAC activity is required for proper chromosome condensation in the mammalian oocyte and that HDACi may induce abnormal chromosome segregation by interfering with both chromosome-microtubule interactions, as well as sister chromatid separation. Thus, HDACi, proposed for cancer therapy, may disrupt the epigenetic status of female germ cells, predisposing oocytes to an¬euploidy at previously unrecognized low doses." @default.
• W2045496528 created "2016-06-24" @default.
• W2045496528 creator A5003188420 @default.
• W2045496528 creator A5032261372 @default.
• W2045496528 creator A5052441271 @default.
• W2045496528 creator A5076500838 @default.
• W2045496528 date "2012-01-01" @default.
• W2045496528 modified "2023-10-05" @default.
• W2045496528 title "Histone hyperacetylation during meiosis interferes with large-scale chromatin remodeling, axial chromatid condensation and sister chromatid separation in the mammalian oocyte" @default.
• W2045496528 cites W1881829782 @default.
• W2045496528 cites W1974805461 @default.
• W2045496528 cites W1981348314 @default.
• W2045496528 cites W1992191647 @default.
• W2045496528 cites W1999586571 @default.
• W2045496528 cites W2001644793 @default.
• W2045496528 cites W2003777386 @default.
• W2045496528 cites W2012212160 @default.
• W2045496528 cites W2019204960 @default.
• W2045496528 cites W2020203570 @default.
• W2045496528 cites W2022018162 @default.
• W2045496528 cites W2025209702 @default.
• W2045496528 cites W2037466043 @default.
• W2045496528 cites W2041689291 @default.
• W2045496528 cites W2043439794 @default.
• W2045496528 cites W2049804461 @default.
• W2045496528 cites W2054831080 @default.
• W2045496528 cites W2068932012 @default.
• W2045496528 cites W2071949364 @default.
• W2045496528 cites W2073157961 @default.
• W2045496528 cites W2076467009 @default.
• W2045496528 cites W2084980375 @default.
• W2045496528 cites W20935937 @default.
• W2045496528 cites W2094892383 @default.
• W2045496528 cites W2110199196 @default.
• W2045496528 cites W2110513131 @default.
• W2045496528 cites W2111494715 @default.
• W2045496528 cites W2112731182 @default.
• W2045496528 cites W2113787496 @default.
• W2045496528 cites W2118972444 @default.
• W2045496528 cites W2121787223 @default.
• W2045496528 cites W2125659069 @default.
• W2045496528 cites W2131278882 @default.
• W2045496528 cites W2132270941 @default.
• W2045496528 cites W2133286080 @default.
• W2045496528 cites W2144778448 @default.
• W2045496528 cites W2146091491 @default.
• W2045496528 cites W2146320180 @default.
• W2045496528 cites W2154026141 @default.
• W2045496528 cites W2154875873 @default.
• W2045496528 cites W2170515091 @default.
• W2045496528 doi "https://doi.org/10.1387/ijdb.120246rd" @default.
• W2045496528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23417411" @default.
• W2045496528 hasPublicationYear "2012" @default.
• W2045496528 type Work @default.
• W2045496528 sameAs 2045496528 @default.
• W2045496528 citedByCount "26" @default.
• W2045496528 countsByYear W20454965282013 @default.
• W2045496528 countsByYear W20454965282014 @default.
• W2045496528 countsByYear W20454965282015 @default.
• W2045496528 countsByYear W20454965282016 @default.
• W2045496528 countsByYear W20454965282017 @default.
• W2045496528 countsByYear W20454965282018 @default.
• W2045496528 countsByYear W20454965282019 @default.
• W2045496528 countsByYear W20454965282021 @default.
• W2045496528 countsByYear W20454965282022 @default.
• W2045496528 countsByYear W20454965282023 @default.
• W2045496528 crossrefType "journal-article" @default.
• W2045496528 hasAuthorship W2045496528A5003188420 @default.
• W2045496528 hasAuthorship W2045496528A5032261372 @default.
• W2045496528 hasAuthorship W2045496528A5052441271 @default.
• W2045496528 hasAuthorship W2045496528A5076500838 @default.
• W2045496528 hasBestOaLocation W20454965281 @default.
• W2045496528 hasConcept C104317684 @default.
• W2045496528 hasConcept C148196450 @default.
• W2045496528 hasConcept C153911025 @default.
• W2045496528 hasConcept C167227067 @default.
• W2045496528 hasConcept C178108356 @default.
• W2045496528 hasConcept C2779085176 @default.
• W2045496528 hasConcept C30481170 @default.
• W2045496528 hasConcept C45413362 @default.
• W2045496528 hasConcept C54355233 @default.
• W2045496528 hasConcept C552990157 @default.
• W2045496528 hasConcept C64927066 @default.
• W2045496528 hasConcept C73397532 @default.
• W2045496528 hasConcept C83640560 @default.
• W2045496528 hasConcept C8502773 @default.
• W2045496528 hasConcept C86803240 @default.
• W2045496528 hasConcept C95444343 @default.
• W2045496528 hasConceptScore W2045496528C104317684 @default.
• W2045496528 hasConceptScore W2045496528C148196450 @default.
• W2045496528 hasConceptScore W2045496528C153911025 @default.
• W2045496528 hasConceptScore W2045496528C167227067 @default.
• W2045496528 hasConceptScore W2045496528C178108356 @default.
• W2045496528 hasConceptScore W2045496528C2779085176 @default.
• W2045496528 hasConceptScore W2045496528C30481170 @default.
• W2045496528 hasConceptScore W2045496528C45413362 @default.
• W2045496528 hasConceptScore W2045496528C54355233 @default.
• W2045496528 hasConceptScore W2045496528C552990157 @default.

• next