Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045496844> ?p ?o ?g. }
- W2045496844 endingPage "5425" @default.
- W2045496844 startingPage "5415" @default.
- W2045496844 abstract "Acute promyelocytic leukemia (APL) is characterized by a block in differentiation and accumulation of promyelocytes in the bone marrow and blood. The majority of APL patients harbor the t(15:17) translocation leading to expression of the fusion protein promyelocytic-retinoic acid receptor alpha. Treatment with retinoic acid leads to degradation of promyelocytic-retinoic acid receptor alpha protein and disappearance of leukemic cells; however, 30% of APL patients relapse after treatment. One potential mechanism for relapse is the persistence of cancer stem cells in hematopoietic organs after treatment. Using a novel sorting strategy we developed to isolate murine myeloid cells at distinct stages of differentiation, we identified a population of committed myeloid cells (CD34(+), c-kit(+), FcgammaRIII/II(+), Gr1(int)) that accumulates in the spleen and bone marrow in a murine model of APL. We observed that these cells are capable of efficiently generating leukemia in recipient mice, demonstrating that this population represents the APL cancer-initiating cell. These cells down-regulate the transcription factor CCAAT/enhancer binding protein alpha (C/EBPalpha) possibly through a methylation-dependent mechanism, indicating that C/EBPalpha deregulation contributes to transformation of APL cancer-initiating cells. Our findings provide further understanding of the biology of APL by demonstrating that a committed transformed progenitor can initiate and propagate the disease." @default.
- W2045496844 created "2016-06-24" @default.
- W2045496844 creator A5003947352 @default.
- W2045496844 creator A5028495282 @default.
- W2045496844 creator A5030798882 @default.
- W2045496844 creator A5041497834 @default.
- W2045496844 creator A5045757268 @default.
- W2045496844 creator A5051795758 @default.
- W2045496844 creator A5065813780 @default.
- W2045496844 creator A5066805987 @default.
- W2045496844 creator A5069595860 @default.
- W2045496844 creator A5077867998 @default.
- W2045496844 creator A5084261517 @default.
- W2045496844 creator A5085760081 @default.
- W2045496844 date "2009-12-24" @default.
- W2045496844 modified "2023-10-18" @default.
- W2045496844 title "Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia" @default.
- W2045496844 cites W1486948598 @default.
- W2045496844 cites W1489323849 @default.
- W2045496844 cites W1502074492 @default.
- W2045496844 cites W1517474771 @default.
- W2045496844 cites W1579062391 @default.
- W2045496844 cites W1589900156 @default.
- W2045496844 cites W1597610606 @default.
- W2045496844 cites W1964622335 @default.
- W2045496844 cites W1973035870 @default.
- W2045496844 cites W1977355465 @default.
- W2045496844 cites W1981044274 @default.
- W2045496844 cites W1983547790 @default.
- W2045496844 cites W1986957385 @default.
- W2045496844 cites W1987598864 @default.
- W2045496844 cites W1993600035 @default.
- W2045496844 cites W1996254162 @default.
- W2045496844 cites W2000537249 @default.
- W2045496844 cites W2007375261 @default.
- W2045496844 cites W2009886857 @default.
- W2045496844 cites W2012661561 @default.
- W2045496844 cites W2027629788 @default.
- W2045496844 cites W2029295361 @default.
- W2045496844 cites W2033718586 @default.
- W2045496844 cites W2044699601 @default.
- W2045496844 cites W2049310238 @default.
- W2045496844 cites W2054715911 @default.
- W2045496844 cites W2060618743 @default.
- W2045496844 cites W2066789082 @default.
- W2045496844 cites W2069532898 @default.
- W2045496844 cites W2075179204 @default.
- W2045496844 cites W2077344790 @default.
- W2045496844 cites W2078863277 @default.
- W2045496844 cites W2079526924 @default.
- W2045496844 cites W2080973982 @default.
- W2045496844 cites W2081736209 @default.
- W2045496844 cites W2083483484 @default.
- W2045496844 cites W2086666061 @default.
- W2045496844 cites W2090786449 @default.
- W2045496844 cites W2100088478 @default.
- W2045496844 cites W2100126911 @default.
- W2045496844 cites W2104052013 @default.
- W2045496844 cites W2110502951 @default.
- W2045496844 cites W2120102447 @default.
- W2045496844 cites W2122742344 @default.
- W2045496844 cites W2125162551 @default.
- W2045496844 cites W2127632559 @default.
- W2045496844 cites W2131411117 @default.
- W2045496844 cites W2135132221 @default.
- W2045496844 cites W2141888384 @default.
- W2045496844 cites W2145302069 @default.
- W2045496844 cites W2147567567 @default.
- W2045496844 cites W2149902033 @default.
- W2045496844 cites W2152414109 @default.
- W2045496844 cites W2279275424 @default.
- W2045496844 cites W2297779503 @default.
- W2045496844 doi "https://doi.org/10.1182/blood-2008-10-182071" @default.
- W2045496844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2798860" @default.
- W2045496844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19797526" @default.
- W2045496844 hasPublicationYear "2009" @default.
- W2045496844 type Work @default.
- W2045496844 sameAs 2045496844 @default.
- W2045496844 citedByCount "117" @default.
- W2045496844 countsByYear W20454968442012 @default.
- W2045496844 countsByYear W20454968442013 @default.
- W2045496844 countsByYear W20454968442014 @default.
- W2045496844 countsByYear W20454968442015 @default.
- W2045496844 countsByYear W20454968442016 @default.
- W2045496844 countsByYear W20454968442017 @default.
- W2045496844 countsByYear W20454968442018 @default.
- W2045496844 countsByYear W20454968442019 @default.
- W2045496844 countsByYear W20454968442020 @default.
- W2045496844 countsByYear W20454968442021 @default.
- W2045496844 countsByYear W20454968442022 @default.
- W2045496844 crossrefType "journal-article" @default.
- W2045496844 hasAuthorship W2045496844A5003947352 @default.
- W2045496844 hasAuthorship W2045496844A5028495282 @default.
- W2045496844 hasAuthorship W2045496844A5030798882 @default.
- W2045496844 hasAuthorship W2045496844A5041497834 @default.
- W2045496844 hasAuthorship W2045496844A5045757268 @default.
- W2045496844 hasAuthorship W2045496844A5051795758 @default.
- W2045496844 hasAuthorship W2045496844A5065813780 @default.