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- W2045496942 abstract "The effect of cortisol administration on the rates of glucose entry and utilization in sheep has been studied by measuring the decline in specific activity of the plasma glucose after the rapid intravenous injection of uniformly C14-labeled glucose in control sheep and in sheep given 50, 100 or 150 mg. cortisol acetate daily for 6 days or more. Cortisol administration resulted in moderate hyperglycemia in sheep fed daily and in those fasted for 10 days. The plasma glucose concentration was positively correlated with the plasma cortisol concentration established by daily intramuscular cortisol administration. Prolonged fasting diminished the rates of glucose entry and utilization measured under steady state conditions from 1.2 mg./Kg./min. 24 hours after feeding to 0.74 mg./Kg./min. on the sixth day of fasting. The glucose entry and utilization rates of control and cortisol-treated sheep were not significantly different, either 24 hours after food, or on the sixth day of fasting, despite the much higher plasma glucose concentrations of the cortisol-treated animals. The results are consistent with an inhibition of glucose utilization by cortisol, leading to accumulation of glucose in the plasma and through this, subsequently, to restoration of a normal rate of glucose utilization, provided re-establishment of glucose homeostasis is not prevented by other factors." @default.
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- W2045496942 date "1966-10-01" @default.
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- W2045496942 title "The influence of cortisol on glucose utilization in sheep" @default.
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- W2045496942 doi "https://doi.org/10.1016/0026-0495(66)90163-6" @default.
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