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• W2045497681 abstract "The very varying length of survival in B cell chronic lymphocytic leukaemia (B-CLL), has stimulated the development of a number of clinical staging systems based on clinical and haematological parameters. Especially the staging systems of Rai et al and of Binet et al have won acceptance, and a combination of these systems has been proposed by the International Workshop on CLL. This system, the International Workshop System, should be used as a reference in all CLL studies with prognostic aspects. The immunophenotype of the B cell in B-CLL is characterized by expression of faint surface membrane immunoglobulin and a number of B cell differentiation antigens, of which CD5 and the mouse erythrocyte receptor are the most important. Normal counterparts have been identified as candidates for the leukaemic target cell. No definite prognostic value of surface membrane immunoglobulin class has yet been established in B-CLL. Chromosome abnormalities have been found in 30 to 50% of B-CLL cases, trisomy 12 being the most frequent finding, followed by 14q+. The prognostic role of trisomy 12 is debated, whereas a concensus is emerging of a poor prognosis associated with multiple cytogenetic abnormalities. In advanced B-CLL, it has been shown that response to treatment is a prerequisite for prolonged survival. The effect of intensive therapy is currently being investigated in several studies by comparison with the effect of chlorambucil and prednisone, till now the primary standard therapy. In a Danish multicentre study, however, prolonged survival following initial treatment with CHOP has not yet been recorded, in spite of a much higher remission rate than with chlorambucil and prednisone." @default.
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• W2045497681 date "2009-04-24" @default.
• W2045497681 modified "2023-10-17" @default.
• W2045497681 title "B cell chronic lymphocytic leukaemia: Recent concepts in classification and treatment" @default.
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• W2045497681 doi "https://doi.org/10.1111/j.1600-0609.1989.tb01236.x" @default.
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