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- W2045500687 abstract "HIV-2 infection in the majority of infected subjects follows an attenuated disease course that distinguishes it from infection with HIV-1. Antigen-specific T cells are pivotal in the management of chronic viral infections but are not sufficient to control viral replication in HIV-1–positive subjects, and their function in HIV-2 infection is not fully established. In a community-based cohort of HIV-2 long-term nonprogressors in rural Guinea-Bissau, we performed what we believe is the first comprehensive analysis of HIV-2–specific immune responses. We demonstrate that Gag is the most immunogenic protein. The magnitude of the IFN-γ immune response to the HIV-2 proteome was inversely correlated with HIV-2 viremia, and this relationship was specifically due to the targeting of Gag. Furthermore, patients with undetectable viremia had greater Gag-specific responses compared with patients with high viral replication. The most frequently recognized peptides clustered within a defined region of Gag, and responses to a single peptide in this region were associated with low viral burden. The consistent relationship between Gag-specific immune responses and viremia control suggests that T cell responses are vital in determining the superior outcome of HIV-2 infection. A better understanding of how HIV-2 infection is controlled may identify correlates of effective protective immunity essential for the design of HIV vaccines." @default.
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- W2045500687 date "2007-10-01" @default.
- W2045500687 modified "2023-09-22" @default.
- W2045500687 title "Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection" @default.
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- W2045500687 doi "https://doi.org/10.1172/jci32380" @default.
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