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• W2045504739 endingPage "1100" @default.
• W2045504739 startingPage "1092" @default.
• W2045504739 abstract "Prostaglandin E2 (PGE2) is an abundant eicosanoid in bone that has been implicated in a number of pathological states associated with bone loss. Interleukin-6 (IL-6) is a cytokine that plays a critical role in bone remodeling and appears to act as a downstream effector of most bone-resorbing agents. In light of the evidence that PGE2 induces IL-6 in the bone environment, this study was designed to investigate whether PGE2 regulated IL-6 expression by osteoblasts. Here we demonstrate that PGE2 is a potent inducer of IL-6 production by fetal rat osteoblasts and synergizes with lipopolysaccharide to enhance IL-6. We show that PGE2 stimulates the activity of the IL-6 promoter in osteoblasts, suggesting that PGE2 controls IL-6 gene expression at least at the transcriptional level. Moreover, we show that PGE2-mediated IL-6 induction is prevented by the cAMP antagonist, Rp-cAMP, and the protein kinase A (PKA) inhibitors, KT5720 and H89. Thus, our data indicate that PGE2 involves the cAMP-PKA signaling pathway to regulate IL-6 gene expression in osteoblasts." @default.
• W2045504739 created "2016-06-24" @default.
• W2045504739 creator A5020420603 @default.
• W2045504739 creator A5028238095 @default.
• W2045504739 creator A5061402186 @default.
• W2045504739 date "1998-07-01" @default.
• W2045504739 modified "2023-10-18" @default.
• W2045504739 title "Regulation of Interleukin-6 Production by Prostaglandin E2 in Fetal Rat Osteoblasts: Role of Protein Kinase A Signaling Pathway" @default.
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• W2045504739 doi "https://doi.org/10.1359/jbmr.1998.13.7.1092" @default.
• W2045504739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9661073" @default.
• W2045504739 hasPublicationYear "1998" @default.
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