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• W2045509432 endingPage "356" @default.
• W2045509432 startingPage "349" @default.
• W2045509432 abstract "In the adult mammalian lung, Ia+ dendritic cells (DC) constitute a significant population of immunologically potent accessory cells that are important in the regulation of immune responses to inhaled antigens. The newborn, in most species, displays an increased susceptibility to sensitization by inhaled antigens; whether an immaturity of pulmonary accessory cells is involved has not been determined. In the present study, the ontogeny and function of these cells were examined in fetal and newborn rats. Cells identified as DC in fetal and newborn rat lungs were Ia+, C11b±, OX41−, OX43−, W3/13−, W3/25−, and OX8−. They were characterized ultrastructurally by an eccentric, lobulated nucleus, a paucity of lysosomes, delicate cytoplasmic processes, and abundant membrane-associated Ia. Ia+ DC were first detected within the pulmonary mesenchyme at day 15 and by day 17 of gestation they were also present within the epithelium lining airways. The appearance of Ia+ DC preceded the migration of either T4 or T8 subclasses of T cells to the lung, the latter becoming significant only after birth, when the newborn was exposed to environmental antigens. In none of the fetal or newborn animals was la detected on alveolar type II cells. The accessory cell function of rat pulmonary DC, isolated from fetuses at 20 and 21 days of gestation and from newborns, was tested by an autologous mixed leukocyte reaction. At 20 and 21 days of gestation, pulmonary DC were 40 and 60% as effective, respectively, in stimulating cell proliferation in purified autologous adult splenic T cells as those isolated from adults. Immediately after birth, the accessory cell function of pulmonary DC was the same as or exceeded that of adults. It is concluded that Ia+ DC populate the fetal lung early in gestation and, although they are functionally immature in the fetal rat, at the time of birth these accessory cells are immunologically competent." @default.
• W2045509432 created "2016-06-24" @default.
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• W2045509432 date "1992-03-01" @default.
• W2045509432 modified "2023-09-30" @default.
• W2045509432 title "Ontogeny of Ia⁺ Accessory Cells in Fetal and Newborn Rat Lung" @default.
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• W2045509432 doi "https://doi.org/10.1165/ajrcmb/6.3.349" @default.
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