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- W20455096 abstract "Protein 53 (p53) is a normal cellular protein bound to the viral transforming oncogene large-T antigen. Mutations in p53 are the most common genetic changes in human cancer. This chapter discusses the normal and abnormal functions of p53 ,its role in primary breast cancer, and the potential therapeutic implications.. p53 could immortalize or transform primary cells in culture and also demonstrate a cooperation with other oncogenes which suggests it as a dominant transforming oncogene. It is a nuclear protein with putative roles in DNA replication, transcription, and cell cycle control. The mutations in p53 and interactions with viral proteins and the loss of heterozygosity is the common observation in human breast cancer. Depending on the predisposing factors, different mutations in p53 are found in different types of cancer. Several groups have analyzed loss of heterozygosity on chromosome 17p in breast cancer. There are two loci on chromosome l7p––one at p53 and one at locus YNZ–22––which are commonly deleted. Several breast-tumor mutations are now sequenced and there is a good correlation of immunochemistry with mutated p53. If p53 had a role early on in the differentiation of breast cancer, then mutations in p53 could trap cells in a proliferating phase." @default.
- W20455096 created "2016-06-24" @default.
- W20455096 creator A5079633934 @default.
- W20455096 date "1992-01-01" @default.
- W20455096 modified "2023-09-25" @default.
- W20455096 title "p53 Expression in Human Breast Cancer" @default.
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- W20455096 doi "https://doi.org/10.1016/s0065-230x(08)60303-6" @default.
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