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- W2045511136 abstract "Specific interactions between the protein-binding sequence of the immunoglobulin transcription regulatory element, the octamer, and Oct proteins have been investigated using a biosensor based on surface plasmon resonance. By analysis of in vitro translated Oct1 and Oct2A with a consensus octamer probe, it was shown that the affinity constant, association rate constant and dissociation rate constant of Oct1 were higher than for Oct2A. The biggest difference was in the association rate constants, but this difference was reduced when an octamer motif containing a point mutation was used as a probe. Elements in the octamer flanking sequence could increase the on-rate of Oct proteins to a mutated octamer while not decreasing the off-rate. Oct-octamer interaction in whole nuclear extracts could be detected readily in the biosensor and adapter interactions with template bound proteins were revealed. Thus, biosensor analysis represent a fast and convenient alternative approach to study specific protein-DNA and protein-protein interactions in analysis of transcriptional regulation." @default.
- W2045511136 created "2016-06-24" @default.
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- W2045511136 date "1995-12-01" @default.
- W2045511136 modified "2023-10-18" @default.
- W2045511136 title "Real-time analysis of Oct protein-octamer interaction and transcription complex assembly" @default.
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- W2045511136 doi "https://doi.org/10.1016/0161-5890(95)00067-4" @default.
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