FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045533090> ?p ?o ?g. }

• W2045533090 endingPage "365" @default.
• W2045533090 startingPage "359" @default.
• W2045533090 abstract "Evidence suggests that the majority of lung cancer patients have tumour-derived genetic alterations in circulating plasma DNA, and that this may be developed as a diagnostic tool. To this end, we have studied 60 individuals attending bronchoscopy clinic, with symptoms suspicious of lung cancer, for genetic alterations in bronchial mucosa biopsy (n = 47) and plasma (n = 40) DNA. Thirteen of 47 individuals from whom biopsies were taken displayed allelic loss of heterozygosity (LOH) in biopsy DNA for at least 1 of 4 markers. All 13 of these individuals had neoplastic tumour cells in their biopsies and were subsequently diagnosed with cancer. Thirteen of 40 individuals from whom plasma was taken displayed a plasma DNA LOH, and 12 of these 13 individuals were subsequently diagnosed with cancer. LOH in plasma was generally representative of LOH in the corresponding biopsy. In terms of sensitivity, using just 4 markers, biopsy LOH and plasma LOH were found in 13 of 44 (30%) and 12 of 29 (41%), respectively, of those patients subsequently diagnosed with cancer. Two patients were positive for LOH in plasma samples that pre-dated a diagnosis of cancer by several months. These data suggest that assay of genetic alterations in circulating plasma DNA may be developed as a useful addition to conventional techniques for the diagnosis of lung cancer." @default.
• W2045533090 created "2016-06-24" @default.
• W2045533090 creator A5008443460 @default.
• W2045533090 creator A5027204574 @default.
• W2045533090 creator A5031729318 @default.
• W2045533090 creator A5035588730 @default.
• W2045533090 creator A5043239257 @default.
• W2045533090 creator A5054326849 @default.
• W2045533090 creator A5077609021 @default.
• W2045533090 creator A5080379639 @default.
• W2045533090 date "2001-02-01" @default.
• W2045533090 modified "2023-10-14" @default.
• W2045533090 title "Genetic alterations in bronchial mucosa and plasma DNA from individuals at high risk of lung cancer" @default.
• W2045533090 cites W1488376984 @default.
• W2045533090 cites W1506214019 @default.
• W2045533090 cites W1550107968 @default.
• W2045533090 cites W1552426876 @default.
• W2045533090 cites W1560377790 @default.
• W2045533090 cites W1626865734 @default.
• W2045533090 cites W1929295557 @default.
• W2045533090 cites W1968331471 @default.
• W2045533090 cites W1979610420 @default.
• W2045533090 cites W1981415358 @default.
• W2045533090 cites W1985797100 @default.
• W2045533090 cites W1986260198 @default.
• W2045533090 cites W1986811979 @default.
• W2045533090 cites W1988812015 @default.
• W2045533090 cites W2008868543 @default.
• W2045533090 cites W2016258565 @default.
• W2045533090 cites W2023020698 @default.
• W2045533090 cites W2040294496 @default.
• W2045533090 cites W2045253685 @default.
• W2045533090 cites W2058858941 @default.
• W2045533090 cites W2069786312 @default.
• W2045533090 cites W2094388972 @default.
• W2045533090 cites W2104996384 @default.
• W2045533090 cites W2108677652 @default.
• W2045533090 cites W2110511887 @default.
• W2045533090 cites W2116392212 @default.
• W2045533090 cites W2119363473 @default.
• W2045533090 cites W2131839889 @default.
• W2045533090 cites W2132696570 @default.
• W2045533090 cites W2142127718 @default.
• W2045533090 cites W2142181731 @default.
• W2045533090 cites W2149443601 @default.
• W2045533090 cites W2152360385 @default.
• W2045533090 cites W2161252269 @default.
• W2045533090 cites W2281741938 @default.
• W2045533090 cites W2316172063 @default.
• W2045533090 cites W65966707 @default.
• W2045533090 cites W2277985727 @default.
• W2045533090 doi "https://doi.org/10.1002/1097-0215(200002)9999:9999<::aid-ijc1058>3.0.co;2-e" @default.
• W2045533090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11169960" @default.
• W2045533090 hasPublicationYear "2001" @default.
• W2045533090 type Work @default.
• W2045533090 sameAs 2045533090 @default.
• W2045533090 citedByCount "47" @default.
• W2045533090 countsByYear W20455330902013 @default.
• W2045533090 countsByYear W20455330902018 @default.
• W2045533090 countsByYear W20455330902019 @default.
• W2045533090 countsByYear W20455330902020 @default.
• W2045533090 crossrefType "journal-article" @default.
• W2045533090 hasAuthorship W2045533090A5008443460 @default.
• W2045533090 hasAuthorship W2045533090A5027204574 @default.
• W2045533090 hasAuthorship W2045533090A5031729318 @default.
• W2045533090 hasAuthorship W2045533090A5035588730 @default.
• W2045533090 hasAuthorship W2045533090A5043239257 @default.
• W2045533090 hasAuthorship W2045533090A5054326849 @default.
• W2045533090 hasAuthorship W2045533090A5077609021 @default.
• W2045533090 hasAuthorship W2045533090A5080379639 @default.
• W2045533090 hasBestOaLocation W20455330901 @default.
• W2045533090 hasConcept C104317684 @default.
• W2045533090 hasConcept C121608353 @default.
• W2045533090 hasConcept C126322002 @default.
• W2045533090 hasConcept C142724271 @default.
• W2045533090 hasConcept C143589142 @default.
• W2045533090 hasConcept C143998085 @default.
• W2045533090 hasConcept C180754005 @default.
• W2045533090 hasConcept C203014093 @default.
• W2045533090 hasConcept C2775934546 @default.
• W2045533090 hasConcept C2776256026 @default.
• W2045533090 hasConcept C2778996910 @default.
• W2045533090 hasConcept C2779529041 @default.
• W2045533090 hasConcept C54355233 @default.
• W2045533090 hasConcept C71924100 @default.
• W2045533090 hasConcept C86803240 @default.
• W2045533090 hasConcept C90924648 @default.
• W2045533090 hasConceptScore W2045533090C104317684 @default.
• W2045533090 hasConceptScore W2045533090C121608353 @default.
• W2045533090 hasConceptScore W2045533090C126322002 @default.
• W2045533090 hasConceptScore W2045533090C142724271 @default.
• W2045533090 hasConceptScore W2045533090C143589142 @default.
• W2045533090 hasConceptScore W2045533090C143998085 @default.
• W2045533090 hasConceptScore W2045533090C180754005 @default.
• W2045533090 hasConceptScore W2045533090C203014093 @default.
• W2045533090 hasConceptScore W2045533090C2775934546 @default.
• W2045533090 hasConceptScore W2045533090C2776256026 @default.
• W2045533090 hasConceptScore W2045533090C2778996910 @default.

• next