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• W2045533890 endingPage "1724" @default.
• W2045533890 startingPage "1717" @default.
• W2045533890 abstract "The effect of the β2-adrenoceptor agonist, terbutaline, was investigated on simultaneously measured force and intracellular free calcium ([Ca2+]i) in intact rat soleus muscle fibres, and on contractile protein function and Ca2+ content of the sarcoplasmic reticulum (SR) in skinned fibres. Terbutaline (10 μM) had no significant effect on either resting force or [Ca2+]i. Exposure to terbutaline increased both the integral of the indo-1 ratio transient and peak twitch force by 37%. At sub-maximal (10 Hz) stimulation frequencies, terbutaline accelerated force relaxation but had highly variable effects on tetanic force amplitude. The corresponding indo-1 ratio transients were significantly larger, and faster to decay than the controls. Terbutaline increased tetanic force at near maximal stimulation frequencies (50 Hz) by increasing tetanic [Ca2+]i. Force relaxation was accelerated at this frequency with no significant change in the indo-1 ratio transient decay rate. All of terbutaline's effects on force and indo-1 ratio transients in intact fibres were completely blocked and reversed by ICI 118551 (1 μM). Mechanically skinned fibres isolated from intact muscles pre-treated with terbutaline showed no significant changes in SR Ca2+ content, myofilament [Ca2+]i-sensitivity or maximum force generating capacity. The results suggest that terbutaline primarily modulates force by altering the amplitude and decay rate of the [Ca2+]i transient via phosphorylation of both the ryanodine receptor (RR) and the SR pump regulatory protein, phospholamban (PLB). The high variability of responses of slow-twitch muscles to β2-agonists probably reflects individual differences in basal phosphorylation levels of PLB relative to that of RR. British Journal of Pharmacology (1999) 126, 1717–1724; doi:10.1038/sj.bjp.0702482" @default.
• W2045533890 created "2016-06-24" @default.
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• W2045533890 date "1999-04-01" @default.
• W2045533890 modified "2023-09-26" @default.
• W2045533890 title "Effects of terbutaline on force and intracellular calcium in slow-twitch skeletal muscle fibres of the rat" @default.
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• W2045533890 doi "https://doi.org/10.1038/sj.bjp.0702482" @default.
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