FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045534080> ?p ?o ?g. }

• W2045534080 endingPage "322" @default.
• W2045534080 startingPage "310" @default.
• W2045534080 abstract "Compound A (CpdA), a plant-derived phenyl aziridine precursor, was recently characterized as a fully dissociated nonsteroidal antiinflammatory agent, acting via activation of the glucocorticoid receptor, thereby down-modulating nuclear factor-kappaB-mediated transactivation, but not supporting glucocorticoid response element-driven gene expression. The present study demonstrates the effectiveness of CpdA in inhibiting the disease progress in experimental autoimmune encephalomyelitis (EAE), a well-characterized animal model of multiple sclerosis. CpdA treatment of mice, both early and at the peak of the disease, markedly suppressed the clinical symptoms of EAE induced by myelin oligodendrocyte glycoprotein peptide immunization. Attenuation of the clinical symptoms of EAE by CpdA was accompanied by reduced leukocyte infiltration in the spinal cord, reduced expression of inflammatory cytokines and chemokines, and reduced neuronal damage and demyelination. In vivo CpdA therapy suppressed the encephalogenicity of myelin oligodendrocyte glycoprotein peptide-specific T cells. Moreover, CpdA was able to inhibit TNF- and lipopolysaccharide-induced nuclear factor-kappaB activation in primary microglial cells in vitro, in a differential mechanistic manner as compared with dexamethasone. Finally, in EAE mice the therapeutic effect of CpdA, in contrast to that of dexamethasone, occurred in the absence of hyperinsulinemia and in the absence of a suppressive effect on the hypothalamic-pituitary-adrenal axis. Based on these results, we propose CpdA as a compound with promising antiinflammatory characteristics useful for therapeutic intervention in multiple sclerosis and other neuroinflammatory diseases." @default.
• W2045534080 created "2016-06-24" @default.
• W2045534080 creator A5009303134 @default.
• W2045534080 creator A5010554402 @default.
• W2045534080 creator A5013264825 @default.
• W2045534080 creator A5018767436 @default.
• W2045534080 creator A5020510395 @default.
• W2045534080 creator A5021593932 @default.
• W2045534080 creator A5046462982 @default.
• W2045534080 creator A5068369664 @default.
• W2045534080 creator A5080918885 @default.
• W2045534080 creator A5084872868 @default.
• W2045534080 date "2010-02-01" @default.
• W2045534080 modified "2023-10-16" @default.
• W2045534080 title "Antiinflammatory Properties of a Plant-Derived Nonsteroidal, Dissociated Glucocorticoid Receptor Modulator in Experimental Autoimmune Encephalomyelitis" @default.
• W2045534080 cites W1524223037 @default.
• W2045534080 cites W1835342283 @default.
• W2045534080 cites W1847842035 @default.
• W2045534080 cites W1869180711 @default.
• W2045534080 cites W1964780858 @default.
• W2045534080 cites W1964883544 @default.
• W2045534080 cites W1966415698 @default.
• W2045534080 cites W1969125125 @default.
• W2045534080 cites W1971449558 @default.
• W2045534080 cites W1986913568 @default.
• W2045534080 cites W1994103165 @default.
• W2045534080 cites W1997103341 @default.
• W2045534080 cites W2021789739 @default.
• W2045534080 cites W2043703663 @default.
• W2045534080 cites W2044045263 @default.
• W2045534080 cites W2047286951 @default.
• W2045534080 cites W2049746643 @default.
• W2045534080 cites W2053125671 @default.
• W2045534080 cites W2056839634 @default.
• W2045534080 cites W2059994807 @default.
• W2045534080 cites W2078111498 @default.
• W2045534080 cites W2079003535 @default.
• W2045534080 cites W2079320514 @default.
• W2045534080 cites W2079322665 @default.
• W2045534080 cites W2083485745 @default.
• W2045534080 cites W2085412596 @default.
• W2045534080 cites W2090804892 @default.
• W2045534080 cites W2092900546 @default.
• W2045534080 cites W2095060581 @default.
• W2045534080 cites W2106471110 @default.
• W2045534080 cites W2109918049 @default.
• W2045534080 cites W2131367762 @default.
• W2045534080 cites W2135268524 @default.
• W2045534080 cites W2150547407 @default.
• W2045534080 cites W2164498996 @default.
• W2045534080 cites W2165787609 @default.
• W2045534080 cites W2168789122 @default.
• W2045534080 cites W2171467864 @default.
• W2045534080 cites W4313335775 @default.
• W2045534080 doi "https://doi.org/10.1210/me.2009-0236" @default.
• W2045534080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5428123" @default.
• W2045534080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28199537" @default.
• W2045534080 hasPublicationYear "2010" @default.
• W2045534080 type Work @default.
• W2045534080 sameAs 2045534080 @default.
• W2045534080 citedByCount "59" @default.
• W2045534080 countsByYear W20455340802012 @default.
• W2045534080 countsByYear W20455340802013 @default.
• W2045534080 countsByYear W20455340802014 @default.
• W2045534080 countsByYear W20455340802015 @default.
• W2045534080 countsByYear W20455340802016 @default.
• W2045534080 countsByYear W20455340802017 @default.
• W2045534080 countsByYear W20455340802018 @default.
• W2045534080 countsByYear W20455340802019 @default.
• W2045534080 countsByYear W20455340802020 @default.
• W2045534080 countsByYear W20455340802021 @default.
• W2045534080 countsByYear W20455340802022 @default.
• W2045534080 crossrefType "journal-article" @default.
• W2045534080 hasAuthorship W2045534080A5009303134 @default.
• W2045534080 hasAuthorship W2045534080A5010554402 @default.
• W2045534080 hasAuthorship W2045534080A5013264825 @default.
• W2045534080 hasAuthorship W2045534080A5018767436 @default.
• W2045534080 hasAuthorship W2045534080A5020510395 @default.
• W2045534080 hasAuthorship W2045534080A5021593932 @default.
• W2045534080 hasAuthorship W2045534080A5046462982 @default.
• W2045534080 hasAuthorship W2045534080A5068369664 @default.
• W2045534080 hasAuthorship W2045534080A5080918885 @default.
• W2045534080 hasAuthorship W2045534080A5084872868 @default.
• W2045534080 hasBestOaLocation W20455340802 @default.
• W2045534080 hasConcept C126322002 @default.
• W2045534080 hasConcept C134018914 @default.
• W2045534080 hasConcept C203014093 @default.
• W2045534080 hasConcept C2777899865 @default.
• W2045534080 hasConcept C2778486448 @default.
• W2045534080 hasConcept C2779357208 @default.
• W2045534080 hasConcept C2780640218 @default.
• W2045534080 hasConcept C2780841215 @default.
• W2045534080 hasConcept C59493245 @default.
• W2045534080 hasConcept C71924100 @default.
• W2045534080 hasConcept C86803240 @default.
• W2045534080 hasConcept C98274493 @default.
• W2045534080 hasConceptScore W2045534080C126322002 @default.
• W2045534080 hasConceptScore W2045534080C134018914 @default.

• next