FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045537093> ?p ?o ?g. }

• W2045537093 endingPage "109" @default.
• W2045537093 startingPage "103" @default.
• W2045537093 abstract "In vitro, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) catalyses the interconversion of active corticosterone and inert 11-dehydrocorticosterone. 11beta-HSD-1 is highly expressed in liver, where the reaction direction is 11beta-reduction, thus potentially increasing intrahepatic active glucocorticoid levels. Inhibition of 11beta-HSD-1 increases insulin sensitivity in humans in vivo suggesting that hepatic 11beta-HSD-1 plays a role in the maintenance or control of key glucocorticoid-regulated metabolic functions. We have selectively repressed hepatic 11beta-HSD-1 in rats by oestradiol administration for 42 days. This nearly completely repressed hepatic 11beta-HSD-1 mRNA expression and enzyme activity and reduced expression of hepatic glucocorticoid-inducible genes including phosphoenolpyruvate carboxykinase (PEPCK), the rate-limiting step in gluconeogenesis. Similar effects were seen after 3 weeks of oestradiol treatment. To examine whether this was due to any direct effect of oestradiol upon PEPCK, the experiment was repeated in adrenalectomised rats+/-glucocorticoid replacement. In adrenalectomised rats, oestradiol did not attenuate hepatic PEPCK, whilst glucocorticoid replacement restored this action. Oestradiol did not alter hepatic metabolism of corticosterone by pathways other than 11beta-HSD-1. These data suggest 11beta-HSD-1 plays an important role in maintaining expression of key glucocorticoid-regulated hepatic transcripts. Enzyme inhibition may provide a useful therapeutic target for manipulating glucose homeostasis." @default.
• W2045537093 created "2016-06-24" @default.
• W2045537093 creator A5016733053 @default.
• W2045537093 creator A5017724906 @default.
• W2045537093 creator A5049128105 @default.
• W2045537093 creator A5064304317 @default.
• W2045537093 creator A5084052287 @default.
• W2045537093 date "1999-01-01" @default.
• W2045537093 modified "2023-10-03" @default.
• W2045537093 title "Interactions between oestradiol and glucocorticoid regulatory effects on liver-specific glucocorticoid-inducible genes: possible evidence for a role of hepatic 11beta-hydroxysteroid dehydrogenase type 1" @default.
• W2045537093 cites W1783500979 @default.
• W2045537093 cites W1966962224 @default.
• W2045537093 cites W1981071038 @default.
• W2045537093 cites W1986842715 @default.
• W2045537093 cites W1990370031 @default.
• W2045537093 cites W1992402057 @default.
• W2045537093 cites W2010827268 @default.
• W2045537093 cites W2019976732 @default.
• W2045537093 cites W2027185047 @default.
• W2045537093 cites W2040851277 @default.
• W2045537093 cites W2049063396 @default.
• W2045537093 cites W2070984897 @default.
• W2045537093 cites W2082130579 @default.
• W2045537093 cites W2134812217 @default.
• W2045537093 cites W2148114970 @default.
• W2045537093 cites W2150925908 @default.
• W2045537093 cites W2160628552 @default.
• W2045537093 cites W63938293 @default.
• W2045537093 doi "https://doi.org/10.1677/joe.0.1600103" @default.
• W2045537093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9854182" @default.
• W2045537093 hasPublicationYear "1999" @default.
• W2045537093 type Work @default.
• W2045537093 sameAs 2045537093 @default.
• W2045537093 citedByCount "62" @default.
• W2045537093 countsByYear W20455370932012 @default.
• W2045537093 countsByYear W20455370932013 @default.
• W2045537093 countsByYear W20455370932014 @default.
• W2045537093 countsByYear W20455370932015 @default.
• W2045537093 countsByYear W20455370932016 @default.
• W2045537093 countsByYear W20455370932019 @default.
• W2045537093 countsByYear W20455370932020 @default.
• W2045537093 countsByYear W20455370932021 @default.
• W2045537093 countsByYear W20455370932023 @default.
• W2045537093 crossrefType "journal-article" @default.
• W2045537093 hasAuthorship W2045537093A5016733053 @default.
• W2045537093 hasAuthorship W2045537093A5017724906 @default.
• W2045537093 hasAuthorship W2045537093A5049128105 @default.
• W2045537093 hasAuthorship W2045537093A5064304317 @default.
• W2045537093 hasAuthorship W2045537093A5084052287 @default.
• W2045537093 hasBestOaLocation W20455370931 @default.
• W2045537093 hasConcept C126322002 @default.
• W2045537093 hasConcept C134018914 @default.
• W2045537093 hasConcept C143937172 @default.
• W2045537093 hasConcept C181199279 @default.
• W2045537093 hasConcept C20904676 @default.
• W2045537093 hasConcept C2777391703 @default.
• W2045537093 hasConcept C2779306644 @default.
• W2045537093 hasConcept C2780087391 @default.
• W2045537093 hasConcept C2780352252 @default.
• W2045537093 hasConcept C2780841215 @default.
• W2045537093 hasConcept C3018667095 @default.
• W2045537093 hasConcept C55493867 @default.
• W2045537093 hasConcept C62231903 @default.
• W2045537093 hasConcept C71315377 @default.
• W2045537093 hasConcept C71924100 @default.
• W2045537093 hasConcept C86803240 @default.
• W2045537093 hasConceptScore W2045537093C126322002 @default.
• W2045537093 hasConceptScore W2045537093C134018914 @default.
• W2045537093 hasConceptScore W2045537093C143937172 @default.
• W2045537093 hasConceptScore W2045537093C181199279 @default.
• W2045537093 hasConceptScore W2045537093C20904676 @default.
• W2045537093 hasConceptScore W2045537093C2777391703 @default.
• W2045537093 hasConceptScore W2045537093C2779306644 @default.
• W2045537093 hasConceptScore W2045537093C2780087391 @default.
• W2045537093 hasConceptScore W2045537093C2780352252 @default.
• W2045537093 hasConceptScore W2045537093C2780841215 @default.
• W2045537093 hasConceptScore W2045537093C3018667095 @default.
• W2045537093 hasConceptScore W2045537093C55493867 @default.
• W2045537093 hasConceptScore W2045537093C62231903 @default.
• W2045537093 hasConceptScore W2045537093C71315377 @default.
• W2045537093 hasConceptScore W2045537093C71924100 @default.
• W2045537093 hasConceptScore W2045537093C86803240 @default.
• W2045537093 hasIssue "1" @default.
• W2045537093 hasLocation W20455370931 @default.
• W2045537093 hasLocation W20455370932 @default.
• W2045537093 hasOpenAccess W2045537093 @default.
• W2045537093 hasPrimaryLocation W20455370931 @default.
• W2045537093 hasRelatedWork W1970091690 @default.
• W2045537093 hasRelatedWork W2015328630 @default.
• W2045537093 hasRelatedWork W2019141845 @default.
• W2045537093 hasRelatedWork W2023696391 @default.
• W2045537093 hasRelatedWork W2050258242 @default.
• W2045537093 hasRelatedWork W2071337848 @default.
• W2045537093 hasRelatedWork W2276893008 @default.
• W2045537093 hasRelatedWork W2473387876 @default.
• W2045537093 hasRelatedWork W4220804802 @default.
• W2045537093 hasRelatedWork W4247840798 @default.
• W2045537093 hasVolume "160" @default.

• next