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- W2045541438 abstract "Abstract The steady state levels of glutamine, glutamate, other amino acids, and ammonia were determined in the brains of mature and senescent C57B1/6J mice. Glutamine was the only amino acid which showed an age-related change. The glutamine concentration in the senescent mouse brain was approximately 50% greater than that in the mature mouse brain. The brain ammonia concentration was increased 60% in the old mice. Alos the activities of glutaminase and γ-glutamyltransferase were determined. These activities were changed very slightly as a function of age, and thus their levels probably do not account for the observed differences in glutamine and ammonia levels. These results indicate that in the brains of senescent mice, more glutamine is synthesized in an attempt to detoxify the higher levels of ammonia." @default.
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- W2045541438 date "1978-01-01" @default.
- W2045541438 modified "2023-10-14" @default.
- W2045541438 title "Glutamine and ammonia metabolism in the brains of senescent mice" @default.
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- W2045541438 doi "https://doi.org/10.1016/0531-5565(78)90020-7" @default.
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