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• W2045543396 abstract "Article Abstract Objective: The present placebo-controlled study evaluated the efficacy, tolerability, and safety of 8-week treatment with agomelatine (25-50 mg/d by mouth) in elderly patients with major depressive disorder (MDD). Method: Elderly outpatients aged ≥ 65 years with a primary diagnosis of moderate to severe episode of recurrent MDD (DSM-IV-TR) were recruited in 27 clinical centers in Argentina, Finland, Mexico, Portugal, and Romania from November 2009 to October 2011. The primary outcome measure was the 17-item Hamilton Depression Rating Scale (HDRS17) total score. Results: A total of 222 elderly patients entered the study (151 in the agomelatine group, 71 in the placebo group), including 69 patients aged 75 years and older. Agomelatine improved depressive symptoms in the elderly population, as evaluated by the HDRS17 total score, in terms of last postbaseline value (agomelatine-placebo difference: mean estimate = 2.67 points; P = .013) and response to treatment (agomelatine, 59.5%; placebo, 38.6%; P = .004). The agomelatine-placebo difference according to the Clinical Global Impressions-Severity of Illness scale (CGI-S) score was 0.48 (0.19). The agomelatine-placebo difference (estimate ) for remission on the HDRS17 was 6.9% (4.7%) and did not achieve statistical significance (P = .179, post hoc analysis). Clinically relevant effects of agomelatine were confirmed on all end points in the subset of severely depressed patients (HDRS17 total score ≥ 25 and CGI-S score ≥ 5 at baseline). Agomelatine was well tolerated by patients, with only minimal distinctions from placebo. Conclusions: The present study provides the first evidence that an 8-week treatment with agomelatine 25-50 mg/d efficiently relieves depressive symptoms and is well tolerated in elderly depressed patients older than 65 years. Trial Registration: Controlled-Trials.com identifier: ISRCTN57507360 J Clin Psychiatry 2013;74(6):587-594 © Copyright 2013 Physicians Postgraduate Press, Inc. Submitted: October 29, 2012; accepted March 19, 2013 (doi:10.4088/JCP.12m08250). Corresponding author: Reinhard Heun, MD, Radbourne Unit, Derby City General Hospital, Uttoxeter Rd, Derby DE22 3NE, United Kingdom (heun@gmx.com)." @default.
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• W2045543396 date "2013-06-15" @default.
• W2045543396 modified "2023-09-22" @default.
• W2045543396 title "The Efficacy of Agomelatine in Elderly Patients With Recurrent Major Depressive Disorder" @default.
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• W2045543396 doi "https://doi.org/10.4088/jcp.12m08250" @default.
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