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- W2045546593 endingPage "1523" @default.
- W2045546593 startingPage "1507" @default.
- W2045546593 abstract "Anaemia is a serious complication of Crohn's disease that triggers hospitalization and, if not interfered with, may lead to death.To systematically summarize and compare the literature on anaemia in Crohn's disease.For this systematic review the literature was searched for English-language articles using anaemia, Crohn* and IBD as key words. 144 articles were identified and sorted according to the following topics: prevalence, aetiology, diagnostic tests and therapy.The reported prevalence of anaemia varied between 6.2% and 73.7%, with higher reported frequencies in older studies and in in-patients. Iron deficiency is the most common underlying condition. Vitamin B12 deficiency is related to the extent of ileal resection but has rarely impact on anaemia. Diagnostic criteria are not established and treatment guidelines are missing. Oral iron supplementation seems effective for short periods but intolerance leads to discontinuation in up to 21%. Eleven of 11 studies show that oral iron enhances intestinal inflammation and colon carcinogenesis in animal models of colitis. Intravenous iron supplementation with iron sucrose has been tested in over 250 Crohn's disease patients, is safe, effective and does not carry such hazards.As disease activity is determining the degree of anaemia in Crohn's disease, implementation of more effective therapy for Crohn's disease will lower its incidence. However, further studies regarding the safety and effectiveness of iron supplementation are needed." @default.
- W2045546593 created "2016-06-24" @default.
- W2045546593 creator A5015970495 @default.
- W2045546593 creator A5021628637 @default.
- W2045546593 date "2006-11-28" @default.
- W2045546593 modified "2023-10-18" @default.
- W2045546593 title "Systematic review: managing anaemia in Crohn's disease" @default.
- W2045546593 cites W1492461201 @default.
- W2045546593 cites W1504139681 @default.
- W2045546593 cites W1568251881 @default.
- W2045546593 cites W1582639556 @default.
- W2045546593 cites W1591222484 @default.
- W2045546593 cites W1593140847 @default.
- W2045546593 cites W1597380779 @default.
- W2045546593 cites W1606079165 @default.
- W2045546593 cites W187840447 @default.
- W2045546593 cites W1924847619 @default.
- W2045546593 cites W1965691919 @default.
- W2045546593 cites W1965703255 @default.
- W2045546593 cites W1968336384 @default.
- W2045546593 cites W1969971578 @default.
- W2045546593 cites W1972486658 @default.
- W2045546593 cites W1972809552 @default.
- W2045546593 cites W1976546496 @default.
- W2045546593 cites W1976786690 @default.
- W2045546593 cites W1978270674 @default.
- W2045546593 cites W1980608581 @default.
- W2045546593 cites W1982712890 @default.
- W2045546593 cites W1983262779 @default.
- W2045546593 cites W1984947782 @default.
- W2045546593 cites W1985623604 @default.
- W2045546593 cites W1986150854 @default.
- W2045546593 cites W1986337203 @default.
- W2045546593 cites W1986482026 @default.
- W2045546593 cites W1988144193 @default.
- W2045546593 cites W1995111193 @default.
- W2045546593 cites W1999416574 @default.
- W2045546593 cites W2000500639 @default.
- W2045546593 cites W2001514221 @default.
- W2045546593 cites W2003087388 @default.
- W2045546593 cites W2008580632 @default.
- W2045546593 cites W2015629799 @default.
- W2045546593 cites W2015787726 @default.
- W2045546593 cites W2016239788 @default.
- W2045546593 cites W2016303433 @default.
- W2045546593 cites W2017329624 @default.
- W2045546593 cites W2017779666 @default.
- W2045546593 cites W2019440184 @default.
- W2045546593 cites W2025343624 @default.
- W2045546593 cites W2027304097 @default.
- W2045546593 cites W2030066954 @default.
- W2045546593 cites W2033611064 @default.
- W2045546593 cites W2038315855 @default.
- W2045546593 cites W2041788840 @default.
- W2045546593 cites W2043530745 @default.
- W2045546593 cites W2043577893 @default.
- W2045546593 cites W2045191157 @default.
- W2045546593 cites W2045402066 @default.
- W2045546593 cites W2045520882 @default.
- W2045546593 cites W2047768662 @default.
- W2045546593 cites W2047957620 @default.
- W2045546593 cites W2048653016 @default.
- W2045546593 cites W2048729604 @default.
- W2045546593 cites W2049376080 @default.
- W2045546593 cites W2050386141 @default.
- W2045546593 cites W2051217274 @default.
- W2045546593 cites W2051856768 @default.
- W2045546593 cites W2052482280 @default.
- W2045546593 cites W2053335820 @default.
- W2045546593 cites W2055277570 @default.
- W2045546593 cites W2055562038 @default.
- W2045546593 cites W2057397552 @default.
- W2045546593 cites W2057994622 @default.
- W2045546593 cites W2061149369 @default.
- W2045546593 cites W2061183782 @default.
- W2045546593 cites W2062786036 @default.
- W2045546593 cites W2062853553 @default.
- W2045546593 cites W2065350405 @default.
- W2045546593 cites W2069657931 @default.
- W2045546593 cites W2077541995 @default.
- W2045546593 cites W2080420604 @default.
- W2045546593 cites W2081824390 @default.
- W2045546593 cites W2082095539 @default.
- W2045546593 cites W2083228900 @default.
- W2045546593 cites W2090198994 @default.
- W2045546593 cites W2093051520 @default.
- W2045546593 cites W2096968696 @default.
- W2045546593 cites W2104438864 @default.
- W2045546593 cites W2105338400 @default.
- W2045546593 cites W2105579244 @default.
- W2045546593 cites W2106879994 @default.
- W2045546593 cites W2109969477 @default.
- W2045546593 cites W2111908321 @default.
- W2045546593 cites W2118455713 @default.
- W2045546593 cites W2123200029 @default.
- W2045546593 cites W2130192910 @default.
- W2045546593 cites W2132517981 @default.
- W2045546593 cites W2135958206 @default.