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- W2045551133 abstract "Human papovavirus 1C virus (JCV) and Simian virus 40 (SV40) tumor or T antigens demonstrate considerable sequence homology which is reflected by antibody cross-reactivity. This similarity raised the possibility that JCV and SV40 T antigen also might contain common cytotoxic T lymphocyte (CTL) recognition epitopes. In this study we identified and mapped such sites on the JCV T antigen. C57BI/6 cell lines transformed by JCV/SV40 T antigen chimeras were generated and tested for susceptibility to lysis by five H-2b restricted SV40-specific CTL clones: Y-1, Y-2, Y-3, Y-4, and Y-5. These CTL clones recognize specific epitopes within amino acids 205–219 (site I), 220–233 (sites 11 and III), 369–511 (site IV), and 489–503 (site V) on SV40 T Ag, respectively. The results show that sites I, 11, III, and IV (recognized by CTL clones Y-1, Y-2, Y-3, and Y-4, respectively) represent common epitopes on SV40 and JCV T antigens. CTL clone Y-5 failed to recognize JCV T antigen indicating that CTL can discriminate between the two antigenically related T antigens." @default.
- W2045551133 created "2016-06-24" @default.
- W2045551133 creator A5020117252 @default.
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- W2045551133 date "1991-07-01" @default.
- W2045551133 modified "2023-10-14" @default.
- W2045551133 title "Localization of common cytotoxic T lymphocyte recognition epitopes on Simian papovavirus sv40 and human papovavirus JC virus T antigens" @default.
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- W2045551133 doi "https://doi.org/10.1016/0042-6822(91)90125-u" @default.
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