FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045552275> ?p ?o ?g. }

• W2045552275 endingPage "816" @default.
• W2045552275 startingPage "810" @default.
• W2045552275 abstract "A significant portion of islet grafts are destroyed by apoptosis and fail to become functional after transplantation. Strategies that enhance islet resistance to apoptosis may prevent graft loss. The aim of this study was to investigate whether overexpression of suppressor of cytokine signaling 1 (SOCS1) in islet grafts could achieve an anti-apoptotic effect and prolong graft survival.We used a chimeric adenovirus vector (Ad5F35) to enhance SOCS1 expression in isolated rat islets, and assessed its protective action against TNF-alpha-induced apoptosis. After transplanting SOCS1-overexpressing islets into allogeneic recipients with streptozotocin-induced diabetes, graft survival and in situ apoptosis were analyzed using immunohistochemistry.The isolated rat islets infected with Ad5F35-SOCS1 showed significantly higher SOCS1 expression than Ad5F35-EGFP and mock infected islets. The Ad5F35 transfection and SOCS1 overexpression on islets did not affect their insulin secretory function. After treatment with rat TNF-alpha and cycloheximide in vitro, Ad5F35-SOCS1 infected islets exhibited a lower apoptotic ratio than controls (Ad5F35-EGFP and mock infected islets). The diabetic recipients transplanted with Ad5F35-SOCS1 infected islets displayed longer time of normoglycemia than recipients transplanted with mock infected islets. Furthermore, histological analysis indicated that the infected grafts with local overexpression of SOCS1 showed decreased apoptosis in the early post-transplant period.These results demonstrate that overexpression of SOCS1 in islet grafts prior to transplantation can significantly protect them from apoptotic loss and prolong their survival. This approach might find a clinical counterpart." @default.
• W2045552275 created "2016-06-24" @default.
• W2045552275 creator A5010949964 @default.
• W2045552275 creator A5013985159 @default.
• W2045552275 creator A5014173912 @default.
• W2045552275 creator A5061215231 @default.
• W2045552275 creator A5079083850 @default.
• W2045552275 creator A5083417334 @default.
• W2045552275 date "2009-06-01" @default.
• W2045552275 modified "2023-10-16" @default.
• W2045552275 title "Overexpression of suppressor of cytokine signaling 1 in islet grafts results in anti-apoptotic effects and prolongs graft survival" @default.
• W2045552275 cites W1508830921 @default.
• W2045552275 cites W1696581921 @default.
• W2045552275 cites W1966568879 @default.
• W2045552275 cites W1972785772 @default.
• W2045552275 cites W1988103735 @default.
• W2045552275 cites W1999820343 @default.
• W2045552275 cites W2002709285 @default.
• W2045552275 cites W2006919788 @default.
• W2045552275 cites W2012549523 @default.
• W2045552275 cites W2013363382 @default.
• W2045552275 cites W2019098957 @default.
• W2045552275 cites W2034902726 @default.
• W2045552275 cites W2035010412 @default.
• W2045552275 cites W2045378112 @default.
• W2045552275 cites W2046236577 @default.
• W2045552275 cites W2052802056 @default.
• W2045552275 cites W2053386318 @default.
• W2045552275 cites W2060560487 @default.
• W2045552275 cites W2070380688 @default.
• W2045552275 cites W2073282913 @default.
• W2045552275 cites W2078657091 @default.
• W2045552275 cites W2088866311 @default.
• W2045552275 cites W2089127654 @default.
• W2045552275 cites W2089477241 @default.
• W2045552275 cites W2101574424 @default.
• W2045552275 cites W2102032120 @default.
• W2045552275 cites W2102387814 @default.
• W2045552275 cites W2106068833 @default.
• W2045552275 cites W2107763843 @default.
• W2045552275 cites W2116345973 @default.
• W2045552275 cites W2116611386 @default.
• W2045552275 cites W2128442314 @default.
• W2045552275 cites W2133186034 @default.
• W2045552275 cites W2137171012 @default.
• W2045552275 cites W2145034520 @default.
• W2045552275 cites W2152000177 @default.
• W2045552275 cites W2153669290 @default.
• W2045552275 cites W2169286453 @default.
• W2045552275 cites W4234446838 @default.
• W2045552275 doi "https://doi.org/10.1016/j.lfs.2009.03.010" @default.
• W2045552275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19344732" @default.
• W2045552275 hasPublicationYear "2009" @default.
• W2045552275 type Work @default.
• W2045552275 sameAs 2045552275 @default.
• W2045552275 citedByCount "10" @default.
• W2045552275 countsByYear W20455522752013 @default.
• W2045552275 countsByYear W20455522752014 @default.
• W2045552275 countsByYear W20455522752016 @default.
• W2045552275 crossrefType "journal-article" @default.
• W2045552275 hasAuthorship W2045552275A5010949964 @default.
• W2045552275 hasAuthorship W2045552275A5013985159 @default.
• W2045552275 hasAuthorship W2045552275A5014173912 @default.
• W2045552275 hasAuthorship W2045552275A5061215231 @default.
• W2045552275 hasAuthorship W2045552275A5079083850 @default.
• W2045552275 hasAuthorship W2045552275A5083417334 @default.
• W2045552275 hasConcept C104317684 @default.
• W2045552275 hasConcept C126322002 @default.
• W2045552275 hasConcept C134018914 @default.
• W2045552275 hasConcept C14077384 @default.
• W2045552275 hasConcept C165220095 @default.
• W2045552275 hasConcept C16685009 @default.
• W2045552275 hasConcept C179185449 @default.
• W2045552275 hasConcept C190283241 @default.
• W2045552275 hasConcept C203014093 @default.
• W2045552275 hasConcept C2778690821 @default.
• W2045552275 hasConcept C2779306644 @default.
• W2045552275 hasConcept C2911091166 @default.
• W2045552275 hasConcept C502942594 @default.
• W2045552275 hasConcept C54009773 @default.
• W2045552275 hasConcept C55493867 @default.
• W2045552275 hasConcept C71924100 @default.
• W2045552275 hasConcept C86803240 @default.
• W2045552275 hasConcept C95444343 @default.
• W2045552275 hasConceptScore W2045552275C104317684 @default.
• W2045552275 hasConceptScore W2045552275C126322002 @default.
• W2045552275 hasConceptScore W2045552275C134018914 @default.
• W2045552275 hasConceptScore W2045552275C14077384 @default.
• W2045552275 hasConceptScore W2045552275C165220095 @default.
• W2045552275 hasConceptScore W2045552275C16685009 @default.
• W2045552275 hasConceptScore W2045552275C179185449 @default.
• W2045552275 hasConceptScore W2045552275C190283241 @default.
• W2045552275 hasConceptScore W2045552275C203014093 @default.
• W2045552275 hasConceptScore W2045552275C2778690821 @default.
• W2045552275 hasConceptScore W2045552275C2779306644 @default.
• W2045552275 hasConceptScore W2045552275C2911091166 @default.
• W2045552275 hasConceptScore W2045552275C502942594 @default.
• W2045552275 hasConceptScore W2045552275C54009773 @default.

• next