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• W2045552980 abstract "In this study, we have demonstrated the presence of melanin-concentrating hormone (MCH) and melanin-concentrating hormone receptor (MCHR1) transcripts in human skin. Sequence analysis confirmed that the transcripts of both genes were identical to those previously found in human brain. In culture, endothelial cells showed pro-MCH expression whereas no signal was found in keratinocytes, melanocytes, and fibroblasts. MCHR1 expression was restricted to melanocytes and melanoma cells. Stimulation of cultured human melanocytes with MCH reduced the α-MSH-induced increase in cAMP production. Furthermore, the melanogenic actions of α-MSH were inhibited by MCH. We propose that the MCH/MCHR1 signalling system is present in human skin and may have a role with the melanocortins in regulating the melanocyte." @default.
• W2045552980 created "2016-06-24" @default.
• W2045552980 creator A5037719200 @default.
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• W2045552980 date "2002-08-01" @default.
• W2045552980 modified "2023-10-05" @default.
• W2045552980 title "Melanin-concentrating hormone and its receptor are expressed and functional in human skin" @default.
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• W2045552980 doi "https://doi.org/10.1016/s0006-291x(02)00932-4" @default.
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