Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045553696> ?p ?o ?g. }
- W2045553696 endingPage "712" @default.
- W2045553696 startingPage "705" @default.
- W2045553696 abstract "The 14-3-3 family of phosphoserine/phosphothreonine-binding proteins dynamically regulates the activity of client proteins in various signaling pathways that control diverse physiological and pathological processes. In response to environmental cues, 14-3-3 proteins orchestrate the highly regulated flow of signals through complex networks of molecular interactions to achieve well-controlled physiological outputs, such as cell proliferation or differentiation. Accumulating evidence now supports the concept that either an abnormal state of 14-3-3 protein expression, or dysregulation of 14-3-3/client protein interactions, contributes to the development of a large number of human diseases. In particular, clinical investigations in the field of oncology have demonstrated a correlation between upregulated 14-3-3 levels and poor survival of cancer patients. These studies highlight the rapid emergence of 14-3-3 proteins as a novel class of molecular target for potential therapeutic intervention. The current status of 14-3-3 modulator discovery is discussed." @default.
- W2045553696 created "2016-06-24" @default.
- W2045553696 creator A5017286737 @default.
- W2045553696 creator A5022871106 @default.
- W2045553696 creator A5025004423 @default.
- W2045553696 creator A5059710197 @default.
- W2045553696 creator A5072454821 @default.
- W2045553696 date "2011-09-01" @default.
- W2045553696 modified "2023-10-01" @default.
- W2045553696 title "14-3-3 proteins as potential therapeutic targets" @default.
- W2045553696 cites W141477066 @default.
- W2045553696 cites W1964200049 @default.
- W2045553696 cites W1964343070 @default.
- W2045553696 cites W1965885767 @default.
- W2045553696 cites W1968945660 @default.
- W2045553696 cites W1973104659 @default.
- W2045553696 cites W1974268113 @default.
- W2045553696 cites W1976728998 @default.
- W2045553696 cites W1977391806 @default.
- W2045553696 cites W1981605166 @default.
- W2045553696 cites W1984343926 @default.
- W2045553696 cites W1989547445 @default.
- W2045553696 cites W1991068648 @default.
- W2045553696 cites W1993362565 @default.
- W2045553696 cites W1993790203 @default.
- W2045553696 cites W1995160625 @default.
- W2045553696 cites W1998653769 @default.
- W2045553696 cites W2000010050 @default.
- W2045553696 cites W2000681550 @default.
- W2045553696 cites W2004162153 @default.
- W2045553696 cites W2004536040 @default.
- W2045553696 cites W2009464342 @default.
- W2045553696 cites W2010322812 @default.
- W2045553696 cites W2010516100 @default.
- W2045553696 cites W2010752097 @default.
- W2045553696 cites W2019502665 @default.
- W2045553696 cites W2021449313 @default.
- W2045553696 cites W2021538852 @default.
- W2045553696 cites W2022483806 @default.
- W2045553696 cites W2024923170 @default.
- W2045553696 cites W2031066708 @default.
- W2045553696 cites W2031308904 @default.
- W2045553696 cites W2033174121 @default.
- W2045553696 cites W2033782334 @default.
- W2045553696 cites W2039369286 @default.
- W2045553696 cites W2042054309 @default.
- W2045553696 cites W2044694582 @default.
- W2045553696 cites W2044712817 @default.
- W2045553696 cites W2050892986 @default.
- W2045553696 cites W2051113108 @default.
- W2045553696 cites W2051766214 @default.
- W2045553696 cites W2056237718 @default.
- W2045553696 cites W2057245516 @default.
- W2045553696 cites W2057887000 @default.
- W2045553696 cites W2059493866 @default.
- W2045553696 cites W2062866488 @default.
- W2045553696 cites W2069477707 @default.
- W2045553696 cites W2071075259 @default.
- W2045553696 cites W2077096999 @default.
- W2045553696 cites W2077179648 @default.
- W2045553696 cites W2077192459 @default.
- W2045553696 cites W2088495902 @default.
- W2045553696 cites W2093187449 @default.
- W2045553696 cites W2097857601 @default.
- W2045553696 cites W2101040637 @default.
- W2045553696 cites W2104146932 @default.
- W2045553696 cites W2106958577 @default.
- W2045553696 cites W2107050791 @default.
- W2045553696 cites W2107243870 @default.
- W2045553696 cites W2110447451 @default.
- W2045553696 cites W2110845720 @default.
- W2045553696 cites W2112511860 @default.
- W2045553696 cites W2114542812 @default.
- W2045553696 cites W2122772601 @default.
- W2045553696 cites W2123061071 @default.
- W2045553696 cites W2125091469 @default.
- W2045553696 cites W2125751525 @default.
- W2045553696 cites W2125939997 @default.
- W2045553696 cites W2126011265 @default.
- W2045553696 cites W2126066196 @default.
- W2045553696 cites W2127217749 @default.
- W2045553696 cites W2130408813 @default.
- W2045553696 cites W2134651466 @default.
- W2045553696 cites W2138062901 @default.
- W2045553696 cites W2139255224 @default.
- W2045553696 cites W2140105522 @default.
- W2045553696 cites W2140272588 @default.
- W2045553696 cites W2141026980 @default.
- W2045553696 cites W2145445113 @default.
- W2045553696 cites W2147582215 @default.
- W2045553696 cites W2148104731 @default.
- W2045553696 cites W2152171710 @default.
- W2045553696 cites W2154254554 @default.
- W2045553696 cites W2154957849 @default.
- W2045553696 cites W2156331971 @default.
- W2045553696 cites W2159582103 @default.
- W2045553696 cites W2160236294 @default.
- W2045553696 cites W2161033372 @default.