FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045557430> ?p ?o ?g. }

• W2045557430 endingPage "207" @default.
• W2045557430 startingPage "202" @default.
• W2045557430 abstract "The purpose of this study was to identify the adenomatous polyposis coli (APC) tumor suppressor gene mutation and level of wild-type p53 protein expression in patients with oral submucous fibrosis (OSF).Cells from OSF and control subjects were cultured in Dulbecco modified Eagle medium with 10% fetal bovine serum at 37 degrees C. Genomic DNA was extracted from cultured cells and used as a template for polymerase chain reaction amplification of the APC tumor suppressor gene. The presence of wild-type p53 protein in cell lysates of cultured cells was analyzed by Western blot. Data were analyzed by the sign test for nonparametric samples and by analysis of variance.The results showed that the APC gene of explant cultured cells from OSF patients (8/8) had a CGA-to-GGA transition mutation at codon 498 that resulted in an Arg-to-Gly missense mutation (P <.01). All (8/8) normal HGF cultures revealed expression of the wild-type APC protein. Cells cultured from 7 of 8 OSF patients were also found to have a single nucleotide deletion at nucleotide 1494 that resulted in creating a stop codon (TGA) at codon 504 (P <.01). This created a premature signal for the endpoint of translation and thus resulted in the generation of a truncated protein product that encodes a polypeptide of 503 amino acid residue. It was found that wild- type p53 protein in human gingival fibroblast cell cultures was significantly higher than in OSF cells (P <.01).Alterations of the APC and wild-type p53 tumor suppressor genes in OSF may imply a risk for progression to oral cancer." @default.
• W2045557430 created "2016-06-24" @default.
• W2045557430 creator A5004937430 @default.
• W2045557430 creator A5030212793 @default.
• W2045557430 creator A5051943635 @default.
• W2045557430 creator A5066353819 @default.
• W2045557430 creator A5073976122 @default.
• W2045557430 creator A5080480512 @default.
• W2045557430 date "2001-08-01" @default.
• W2045557430 modified "2023-10-14" @default.
• W2045557430 title "Adenomatous polyposis coli gene mutation and decreased wild- type p53 protein expression in oral submucous fibrosis: A preliminary investigation" @default.
• W2045557430 cites W1964311602 @default.
• W2045557430 cites W1975407594 @default.
• W2045557430 cites W1979618971 @default.
• W2045557430 cites W1993243220 @default.
• W2045557430 cites W1997699507 @default.
• W2045557430 cites W2003375683 @default.
• W2045557430 cites W2003694128 @default.
• W2045557430 cites W2006874765 @default.
• W2045557430 cites W2015519364 @default.
• W2045557430 cites W2018158778 @default.
• W2045557430 cites W2029379351 @default.
• W2045557430 cites W2033404080 @default.
• W2045557430 cites W2036541245 @default.
• W2045557430 cites W2037321928 @default.
• W2045557430 cites W2046098239 @default.
• W2045557430 cites W2047939159 @default.
• W2045557430 cites W2058403714 @default.
• W2045557430 cites W2060569126 @default.
• W2045557430 cites W2064195641 @default.
• W2045557430 cites W2064583952 @default.
• W2045557430 cites W2069426829 @default.
• W2045557430 cites W2070061120 @default.
• W2045557430 cites W2070434126 @default.
• W2045557430 cites W2072340377 @default.
• W2045557430 cites W2093531978 @default.
• W2045557430 cites W2118184847 @default.
• W2045557430 cites W2132936733 @default.
• W2045557430 cites W2135876768 @default.
• W2045557430 cites W2144521853 @default.
• W2045557430 cites W2158303757 @default.
• W2045557430 cites W2159429612 @default.
• W2045557430 cites W2161765765 @default.
• W2045557430 cites W2167515636 @default.
• W2045557430 cites W2233205638 @default.
• W2045557430 cites W2328289020 @default.
• W2045557430 cites W2413460136 @default.
• W2045557430 cites W332662814 @default.
• W2045557430 cites W80298113 @default.
• W2045557430 doi "https://doi.org/10.1067/moe.2001.116816" @default.
• W2045557430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11505268" @default.
• W2045557430 hasPublicationYear "2001" @default.
• W2045557430 type Work @default.
• W2045557430 sameAs 2045557430 @default.
• W2045557430 citedByCount "19" @default.
• W2045557430 countsByYear W20455574302012 @default.
• W2045557430 countsByYear W20455574302013 @default.
• W2045557430 countsByYear W20455574302014 @default.
• W2045557430 countsByYear W20455574302015 @default.
• W2045557430 countsByYear W20455574302016 @default.
• W2045557430 countsByYear W20455574302019 @default.
• W2045557430 countsByYear W20455574302021 @default.
• W2045557430 crossrefType "journal-article" @default.
• W2045557430 hasAuthorship W2045557430A5004937430 @default.
• W2045557430 hasAuthorship W2045557430A5030212793 @default.
• W2045557430 hasAuthorship W2045557430A5051943635 @default.
• W2045557430 hasAuthorship W2045557430A5066353819 @default.
• W2045557430 hasAuthorship W2045557430A5073976122 @default.
• W2045557430 hasAuthorship W2045557430A5080480512 @default.
• W2045557430 hasConcept C104317684 @default.
• W2045557430 hasConcept C121608353 @default.
• W2045557430 hasConcept C142724271 @default.
• W2045557430 hasConcept C143065580 @default.
• W2045557430 hasConcept C153911025 @default.
• W2045557430 hasConcept C176944494 @default.
• W2045557430 hasConcept C207583985 @default.
• W2045557430 hasConcept C2776415932 @default.
• W2045557430 hasConcept C2778237340 @default.
• W2045557430 hasConcept C2780672762 @default.
• W2045557430 hasConcept C501734568 @default.
• W2045557430 hasConcept C526805850 @default.
• W2045557430 hasConcept C54355233 @default.
• W2045557430 hasConcept C71924100 @default.
• W2045557430 hasConcept C75563809 @default.
• W2045557430 hasConcept C86803240 @default.
• W2045557430 hasConceptScore W2045557430C104317684 @default.
• W2045557430 hasConceptScore W2045557430C121608353 @default.
• W2045557430 hasConceptScore W2045557430C142724271 @default.
• W2045557430 hasConceptScore W2045557430C143065580 @default.
• W2045557430 hasConceptScore W2045557430C153911025 @default.
• W2045557430 hasConceptScore W2045557430C176944494 @default.
• W2045557430 hasConceptScore W2045557430C207583985 @default.
• W2045557430 hasConceptScore W2045557430C2776415932 @default.
• W2045557430 hasConceptScore W2045557430C2778237340 @default.
• W2045557430 hasConceptScore W2045557430C2780672762 @default.
• W2045557430 hasConceptScore W2045557430C501734568 @default.
• W2045557430 hasConceptScore W2045557430C526805850 @default.
• W2045557430 hasConceptScore W2045557430C54355233 @default.

• next