FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045558844> ?p ?o ?g. }

• W2045558844 endingPage "243" @default.
• W2045558844 startingPage "233" @default.
• W2045558844 abstract "Global deletion of microsomal prostaglandin E synthase 1 (mPGES-1) in mice attenuates the response to vascular injury without a predisposition to thrombogenesis or hypertension. However, enzyme deletion results in cell-specific differential use by prostaglandin synthases of the accumulated prostaglandin H(2) substrate. Here, we generated mice deficient in mPGES-1 in vascular smooth muscle cells, endothelial cells, and myeloid cells further to elucidate the cardiovascular function of this enzyme.Vascular smooth muscle cell and endothelial cell mPGES-1 deletion did not alter blood pressure at baseline or in response to a high-salt diet. The propensity to evoked macrovascular and microvascular thrombogenesis was also unaltered. However, both vascular smooth muscle cell and endothelial cell mPGES-1-deficient mice exhibited a markedly exaggerated neointimal hyperplastic response to wire injury of the femoral artery in comparison to their littermate controls. The hyperplasia was associated with increased proliferating cell nuclear antigen and tenascin-C expression. In contrast, the response to injury was markedly suppressed by myeloid cell depletion of mPGES-1 with decreased hyperplasia, leukocyte infiltration, and expression of proliferating cell nuclear antigen and tenascin-C. Conditioned medium derived from mPGES-1-deficient macrophages less potently induced vascular smooth muscle cell proliferation and migration than that from wild-type macrophages.Deletion of mPGES-1 in the vasculature and myeloid cells differentially modulates the response to vascular injury, implicating macrophage mPGES-1 as a cardiovascular drug target." @default.
• W2045558844 created "2016-06-24" @default.
• W2045558844 creator A5012747435 @default.
• W2045558844 creator A5014938692 @default.
• W2045558844 creator A5028629304 @default.
• W2045558844 creator A5028802207 @default.
• W2045558844 creator A5033788719 @default.
• W2045558844 creator A5044124013 @default.
• W2045558844 creator A5061568119 @default.
• W2045558844 date "2013-01-15" @default.
• W2045558844 modified "2023-10-17" @default.
• W2045558844 title "Cell Selective Cardiovascular Biology of Microsomal Prostaglandin E Synthase-1" @default.
• W2045558844 cites W1523714680 @default.
• W2045558844 cites W1595293335 @default.
• W2045558844 cites W1970246174 @default.
• W2045558844 cites W1971246001 @default.
• W2045558844 cites W1973222972 @default.
• W2045558844 cites W1978665448 @default.
• W2045558844 cites W1983735472 @default.
• W2045558844 cites W1984532139 @default.
• W2045558844 cites W1992319914 @default.
• W2045558844 cites W1993913999 @default.
• W2045558844 cites W1996692411 @default.
• W2045558844 cites W2006306072 @default.
• W2045558844 cites W2010477133 @default.
• W2045558844 cites W2015877067 @default.
• W2045558844 cites W2018716226 @default.
• W2045558844 cites W2021909367 @default.
• W2045558844 cites W2025691675 @default.
• W2045558844 cites W2034845019 @default.
• W2045558844 cites W2035455139 @default.
• W2045558844 cites W2035522549 @default.
• W2045558844 cites W2035895920 @default.
• W2045558844 cites W2038126877 @default.
• W2045558844 cites W2039258264 @default.
• W2045558844 cites W2041684402 @default.
• W2045558844 cites W2043956359 @default.
• W2045558844 cites W2049772971 @default.
• W2045558844 cites W2052894211 @default.
• W2045558844 cites W2053067012 @default.
• W2045558844 cites W2054761284 @default.
• W2045558844 cites W2055691692 @default.
• W2045558844 cites W2062244250 @default.
• W2045558844 cites W2081026902 @default.
• W2045558844 cites W2087716704 @default.
• W2045558844 cites W2096679097 @default.
• W2045558844 cites W2096874183 @default.
• W2045558844 cites W2097512416 @default.
• W2045558844 cites W2097705351 @default.
• W2045558844 cites W2099885559 @default.
• W2045558844 cites W2105130833 @default.
• W2045558844 cites W2108486099 @default.
• W2045558844 cites W2115622309 @default.
• W2045558844 cites W2117633806 @default.
• W2045558844 cites W2121043418 @default.
• W2045558844 cites W2124096407 @default.
• W2045558844 cites W2129049437 @default.
• W2045558844 cites W2129935236 @default.
• W2045558844 cites W2145772474 @default.
• W2045558844 cites W2147330842 @default.
• W2045558844 cites W2155913937 @default.
• W2045558844 cites W2162392926 @default.
• W2045558844 cites W2165011857 @default.
• W2045558844 cites W2168581452 @default.
• W2045558844 doi "https://doi.org/10.1161/circulationaha.112.119479" @default.
• W2045558844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3546279" @default.
• W2045558844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23204105" @default.
• W2045558844 hasPublicationYear "2013" @default.
• W2045558844 type Work @default.
• W2045558844 sameAs 2045558844 @default.
• W2045558844 citedByCount "40" @default.
• W2045558844 countsByYear W20455588442013 @default.
• W2045558844 countsByYear W20455588442014 @default.
• W2045558844 countsByYear W20455588442015 @default.
• W2045558844 countsByYear W20455588442016 @default.
• W2045558844 countsByYear W20455588442017 @default.
• W2045558844 countsByYear W20455588442018 @default.
• W2045558844 countsByYear W20455588442019 @default.
• W2045558844 countsByYear W20455588442020 @default.
• W2045558844 countsByYear W20455588442021 @default.
• W2045558844 countsByYear W20455588442022 @default.
• W2045558844 crossrefType "journal-article" @default.
• W2045558844 hasAuthorship W2045558844A5012747435 @default.
• W2045558844 hasAuthorship W2045558844A5014938692 @default.
• W2045558844 hasAuthorship W2045558844A5028629304 @default.
• W2045558844 hasAuthorship W2045558844A5028802207 @default.
• W2045558844 hasAuthorship W2045558844A5033788719 @default.
• W2045558844 hasAuthorship W2045558844A5044124013 @default.
• W2045558844 hasAuthorship W2045558844A5061568119 @default.
• W2045558844 hasBestOaLocation W20455588441 @default.
• W2045558844 hasConcept C123012128 @default.
• W2045558844 hasConcept C126322002 @default.
• W2045558844 hasConcept C134018914 @default.
• W2045558844 hasConcept C1491633281 @default.
• W2045558844 hasConcept C202751555 @default.
• W2045558844 hasConcept C2777562237 @default.
• W2045558844 hasConcept C2779395532 @default.
• W2045558844 hasConcept C2780664492 @default.

• next