FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045559876> ?p ?o ?g. }

• W2045559876 abstract "Thyronamines (TAM), recently described endogenous signaling molecules, exert metabolic and pharmacological actions partly opposing those of the thyromimetic hormone T(3). TAM biosynthesis from thyroid hormone (TH) precursors requires decarboxylation of the L-alanine side chain and several deiodination steps to convert e.g. L-thyroxine (T(4)) into the most potent 3-T(1)AM. Aromatic L-amino acid decarboxylase (AADC) was proposed to mediate TAM biosynthesis via decarboxylation of TH. This hypothesis was tested by incubating recombinant human AADC, which actively catalyzes dopamine production from DOPA, with several TH. Under all reaction conditions tested, AADC failed to catalyze TH decarboxylation, thus challenging the initial hypothesis. These in vitro observations are supported by detection of 3-T(1)AM in plasma of patients with AADC-deficiency at levels (46 ± 18 nM, n=4) similar to those of healthy controls. Therefore, we propose that the enzymatic decarboxylation needed to form TAM from TH is catalyzed by another unique, perhaps TH-specific, decarboxylase." @default.
• W2045559876 created "2016-06-24" @default.
• W2045559876 creator A5017706607 @default.
• W2045559876 creator A5019435104 @default.
• W2045559876 creator A5034531104 @default.
• W2045559876 creator A5043750925 @default.
• W2045559876 creator A5052536282 @default.
• W2045559876 creator A5053126814 @default.
• W2045559876 creator A5054252029 @default.
• W2045559876 creator A5072499212 @default.
• W2045559876 creator A5072515956 @default.
• W2045559876 creator A5077836954 @default.
• W2045559876 creator A5090027115 @default.
• W2045559876 date "2012-02-01" @default.
• W2045559876 modified "2023-10-02" @default.
• W2045559876 title "Does the aromatic l-amino acid decarboxylase contribute to thyronamine biosynthesis?" @default.
• W2045559876 cites W1966176550 @default.
• W2045559876 cites W1968107171 @default.
• W2045559876 cites W1977659644 @default.
• W2045559876 cites W1980651541 @default.
• W2045559876 cites W1987053907 @default.
• W2045559876 cites W1987429800 @default.
• W2045559876 cites W1989823250 @default.
• W2045559876 cites W1994509226 @default.
• W2045559876 cites W1999198812 @default.
• W2045559876 cites W1999610793 @default.
• W2045559876 cites W2008259325 @default.
• W2045559876 cites W2013115524 @default.
• W2045559876 cites W2016922647 @default.
• W2045559876 cites W2018867501 @default.
• W2045559876 cites W2025667943 @default.
• W2045559876 cites W2026850284 @default.
• W2045559876 cites W2042163502 @default.
• W2045559876 cites W2053010796 @default.
• W2045559876 cites W2062594762 @default.
• W2045559876 cites W2063465801 @default.
• W2045559876 cites W2067771570 @default.
• W2045559876 cites W2071408780 @default.
• W2045559876 cites W2074202394 @default.
• W2045559876 cites W2074532062 @default.
• W2045559876 cites W2084208740 @default.
• W2045559876 cites W2086907474 @default.
• W2045559876 cites W2104017463 @default.
• W2045559876 cites W2104181172 @default.
• W2045559876 cites W2107511244 @default.
• W2045559876 cites W2119045428 @default.
• W2045559876 cites W2123521364 @default.
• W2045559876 cites W2136133737 @default.
• W2045559876 cites W2137939015 @default.
• W2045559876 cites W2143079214 @default.
• W2045559876 cites W2154261456 @default.
• W2045559876 cites W2155698899 @default.
• W2045559876 cites W2160583880 @default.
• W2045559876 cites W2162722072 @default.
• W2045559876 cites W2163317012 @default.
• W2045559876 cites W2165732918 @default.
• W2045559876 cites W2166082696 @default.
• W2045559876 cites W2217113099 @default.
• W2045559876 cites W2489746220 @default.
• W2045559876 cites W2748821656 @default.
• W2045559876 doi "https://doi.org/10.1016/j.mce.2011.10.024" @default.
• W2045559876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22061622" @default.
• W2045559876 hasPublicationYear "2012" @default.
• W2045559876 type Work @default.
• W2045559876 sameAs 2045559876 @default.
• W2045559876 citedByCount "34" @default.
• W2045559876 countsByYear W20455598762012 @default.
• W2045559876 countsByYear W20455598762013 @default.
• W2045559876 countsByYear W20455598762014 @default.
• W2045559876 countsByYear W20455598762015 @default.
• W2045559876 countsByYear W20455598762016 @default.
• W2045559876 countsByYear W20455598762017 @default.
• W2045559876 countsByYear W20455598762018 @default.
• W2045559876 countsByYear W20455598762019 @default.
• W2045559876 countsByYear W20455598762021 @default.
• W2045559876 crossrefType "journal-article" @default.
• W2045559876 hasAuthorship W2045559876A5017706607 @default.
• W2045559876 hasAuthorship W2045559876A5019435104 @default.
• W2045559876 hasAuthorship W2045559876A5034531104 @default.
• W2045559876 hasAuthorship W2045559876A5043750925 @default.
• W2045559876 hasAuthorship W2045559876A5052536282 @default.
• W2045559876 hasAuthorship W2045559876A5053126814 @default.
• W2045559876 hasAuthorship W2045559876A5054252029 @default.
• W2045559876 hasAuthorship W2045559876A5072499212 @default.
• W2045559876 hasAuthorship W2045559876A5072515956 @default.
• W2045559876 hasAuthorship W2045559876A5077836954 @default.
• W2045559876 hasAuthorship W2045559876A5090027115 @default.
• W2045559876 hasConcept C161790260 @default.
• W2045559876 hasConcept C181199279 @default.
• W2045559876 hasConcept C185592680 @default.
• W2045559876 hasConcept C192989942 @default.
• W2045559876 hasConcept C202751555 @default.
• W2045559876 hasConcept C2779856020 @default.
• W2045559876 hasConcept C2780595602 @default.
• W2045559876 hasConcept C2780627266 @default.
• W2045559876 hasConcept C515207424 @default.
• W2045559876 hasConcept C553450214 @default.
• W2045559876 hasConcept C55493867 @default.
• W2045559876 hasConcept C58824617 @default.
• W2045559876 hasConcept C71240020 @default.

• next