FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045561472> ?p ?o ?g. }

• W2045561472 endingPage "9048" @default.
• W2045561472 startingPage "9039" @default.
• W2045561472 abstract "Fabry disease is an X-linked lysosomal storage disorder caused by a deficiency of the enzyme α-galactosidase A, which results in the progressive accumulation of glycosphingolipids. In addition to the two biomarkers, globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3), which are routinely used for detection and high-risk screening of Fabry disease patients, novel urinary Gb3-related isoforms/analogues as well as newly defined lyso-Gb3 analogues in plasma and urine from Fabry patients have recently been described by our group. The aim of this study was to extend our recent analyses to identify and evaluate new potential Gb3-related biomarkers in the plasma of untreated male Fabry disease patients using a mass spectrometry metabolomic approach. A multivariate statistical analysis revealed five Gb3-related novel biomarkers in the plasma of male Fabry patients. Three of these new biomarkers correspond to Gb3, which has an extra double bond on the sphingosine with C16:0, C18:0, and C22:1 fatty acid chains. The fourth biomarker corresponds to a mixture of two structural isomers, the first with a d16:1 sphingosine and a C16:0 fatty acid and the second with a d18:1 sphingosine and a C14:0 fatty acid. To our knowledge, it is the first time that a Gb3 analogue with a d16:1 sphingosine moiety has been reported. In addition, this Gb3 analogue was also present in its methylated form. These biomarkers are part of a metabolic profile that may provide insight into the pathophysiology of Fabry disease." @default.
• W2045561472 created "2016-06-24" @default.
• W2045561472 creator A5016872045 @default.
• W2045561472 creator A5019790889 @default.
• W2045561472 creator A5082690828 @default.
• W2045561472 date "2013-09-11" @default.
• W2045561472 modified "2023-10-16" @default.
• W2045561472 title "A Metabolomic Study To Identify New Globotriaosylceramide-Related Biomarkers in the Plasma of Fabry Disease Patients" @default.
• W2045561472 cites W1534234912 @default.
• W2045561472 cites W1860232999 @default.
• W2045561472 cites W1974346904 @default.
• W2045561472 cites W1985768899 @default.
• W2045561472 cites W1999926126 @default.
• W2045561472 cites W2006493979 @default.
• W2045561472 cites W2011864674 @default.
• W2045561472 cites W2023001129 @default.
• W2045561472 cites W2026893678 @default.
• W2045561472 cites W2036369568 @default.
• W2045561472 cites W2041715026 @default.
• W2045561472 cites W2042609729 @default.
• W2045561472 cites W2060838050 @default.
• W2045561472 cites W2073816000 @default.
• W2045561472 cites W2074239771 @default.
• W2045561472 cites W2082514851 @default.
• W2045561472 cites W2092169757 @default.
• W2045561472 cites W2093722439 @default.
• W2045561472 cites W2097776291 @default.
• W2045561472 cites W2107743168 @default.
• W2045561472 cites W2131897222 @default.
• W2045561472 cites W2137567062 @default.
• W2045561472 cites W2145826370 @default.
• W2045561472 cites W2146877343 @default.
• W2045561472 cites W2147431297 @default.
• W2045561472 cites W2150885355 @default.
• W2045561472 cites W4211088838 @default.
• W2045561472 doi "https://doi.org/10.1021/ac401542k" @default.
• W2045561472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23968398" @default.
• W2045561472 hasPublicationYear "2013" @default.
• W2045561472 type Work @default.
• W2045561472 sameAs 2045561472 @default.
• W2045561472 citedByCount "52" @default.
• W2045561472 countsByYear W20455614722014 @default.
• W2045561472 countsByYear W20455614722015 @default.
• W2045561472 countsByYear W20455614722016 @default.
• W2045561472 countsByYear W20455614722017 @default.
• W2045561472 countsByYear W20455614722018 @default.
• W2045561472 countsByYear W20455614722019 @default.
• W2045561472 countsByYear W20455614722020 @default.
• W2045561472 countsByYear W20455614722021 @default.
• W2045561472 countsByYear W20455614722022 @default.
• W2045561472 countsByYear W20455614722023 @default.
• W2045561472 crossrefType "journal-article" @default.
• W2045561472 hasAuthorship W2045561472A5016872045 @default.
• W2045561472 hasAuthorship W2045561472A5019790889 @default.
• W2045561472 hasAuthorship W2045561472A5082690828 @default.
• W2045561472 hasConcept C104317684 @default.
• W2045561472 hasConcept C124535831 @default.
• W2045561472 hasConcept C126322002 @default.
• W2045561472 hasConcept C170493617 @default.
• W2045561472 hasConcept C185592680 @default.
• W2045561472 hasConcept C21565614 @default.
• W2045561472 hasConcept C2776788019 @default.
• W2045561472 hasConcept C2776931407 @default.
• W2045561472 hasConcept C2777404818 @default.
• W2045561472 hasConcept C2777687718 @default.
• W2045561472 hasConcept C2778703144 @default.
• W2045561472 hasConcept C2779134260 @default.
• W2045561472 hasConcept C2781197716 @default.
• W2045561472 hasConcept C43617362 @default.
• W2045561472 hasConcept C46111723 @default.
• W2045561472 hasConcept C55493867 @default.
• W2045561472 hasConcept C61705674 @default.
• W2045561472 hasConcept C71924100 @default.
• W2045561472 hasConceptScore W2045561472C104317684 @default.
• W2045561472 hasConceptScore W2045561472C124535831 @default.
• W2045561472 hasConceptScore W2045561472C126322002 @default.
• W2045561472 hasConceptScore W2045561472C170493617 @default.
• W2045561472 hasConceptScore W2045561472C185592680 @default.
• W2045561472 hasConceptScore W2045561472C21565614 @default.
• W2045561472 hasConceptScore W2045561472C2776788019 @default.
• W2045561472 hasConceptScore W2045561472C2776931407 @default.
• W2045561472 hasConceptScore W2045561472C2777404818 @default.
• W2045561472 hasConceptScore W2045561472C2777687718 @default.
• W2045561472 hasConceptScore W2045561472C2778703144 @default.
• W2045561472 hasConceptScore W2045561472C2779134260 @default.
• W2045561472 hasConceptScore W2045561472C2781197716 @default.
• W2045561472 hasConceptScore W2045561472C43617362 @default.
• W2045561472 hasConceptScore W2045561472C46111723 @default.
• W2045561472 hasConceptScore W2045561472C55493867 @default.
• W2045561472 hasConceptScore W2045561472C61705674 @default.
• W2045561472 hasConceptScore W2045561472C71924100 @default.
• W2045561472 hasIssue "19" @default.
• W2045561472 hasLocation W20455614721 @default.
• W2045561472 hasLocation W20455614722 @default.
• W2045561472 hasOpenAccess W2045561472 @default.
• W2045561472 hasPrimaryLocation W20455614721 @default.
• W2045561472 hasRelatedWork W177438411 @default.
• W2045561472 hasRelatedWork W1994786856 @default.

• next