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- W2045562899 abstract "AD (Alzheimer's disease) is a progressive neurodegenerative disease of unknown origin. Despite questions as to the underlying cause(s) of this disease, shared risk factors for both AD and atherosclerotic cardiovascular disease indicate that vascular mechanisms may critically contribute to the development and progression of both AD and atherosclerosis. An increased risk of developing AD is linked to the presence of the apoE4 (apolipoprotein E4) allele, which is also strongly associated with increased risk of developing atherosclerotic cardiovascular disease. Recent studies also indicate that cardiovascular risk factors, including elevated blood cholesterol and triacylglycerol (triglyceride), increase the likelihood of AD and vascular dementia. Lipids and lipoproteins in the circulation interact intimately with the cerebrovasculature, and may have important effects on its constituent brain microvascular endothelial cells and the adjoining astrocytes, which are components of the neurovascular unit. The present review will examine the potential mechanisms for understanding the contributions of vascular factors, including lipids, lipoproteins and cerebrovascular Abeta (amyloid beta), to AD, and suggest therapeutic strategies for the attenuation of this devastating disease process. Specifically, we will focus on the actions of apoE, TGRLs (triacylglycerol-rich lipoproteins) and TGRL lipolysis products on injury of the neurovascular unit and increases in blood-brain barrier permeability." @default.
- W2045562899 created "2016-06-24" @default.
- W2045562899 creator A5009593108 @default.
- W2045562899 creator A5069169318 @default.
- W2045562899 date "2010-08-05" @default.
- W2045562899 modified "2023-10-13" @default.
- W2045562899 title "The vascular contribution to Alzheimer's disease" @default.
- W2045562899 cites W1414030173 @default.
- W2045562899 cites W1445386358 @default.
- W2045562899 cites W1509846655 @default.
- W2045562899 cites W1529259401 @default.
- W2045562899 cites W1546262989 @default.
- W2045562899 cites W1552209891 @default.
- W2045562899 cites W1580706769 @default.
- W2045562899 cites W1582832380 @default.
- W2045562899 cites W1590756 @default.
- W2045562899 cites W1603930029 @default.
- W2045562899 cites W1657989568 @default.
- W2045562899 cites W1749911542 @default.
- W2045562899 cites W184507775 @default.
- W2045562899 cites W1920265813 @default.
- W2045562899 cites W1964203272 @default.
- W2045562899 cites W1965334291 @default.
- W2045562899 cites W1967659527 @default.
- W2045562899 cites W1968467234 @default.
- W2045562899 cites W1971796665 @default.
- W2045562899 cites W1971963029 @default.
- W2045562899 cites W1973027129 @default.
- W2045562899 cites W1973700541 @default.
- W2045562899 cites W1976390944 @default.
- W2045562899 cites W1976725721 @default.
- W2045562899 cites W1977960636 @default.
- W2045562899 cites W1978993923 @default.
- W2045562899 cites W1980029336 @default.
- W2045562899 cites W1981711337 @default.
- W2045562899 cites W1984077928 @default.
- W2045562899 cites W1984974782 @default.
- W2045562899 cites W1985353082 @default.
- W2045562899 cites W1985623563 @default.
- W2045562899 cites W1987959713 @default.
- W2045562899 cites W1990027951 @default.
- W2045562899 cites W1991867131 @default.
- W2045562899 cites W1992758695 @default.
- W2045562899 cites W1993669636 @default.
- W2045562899 cites W1994509415 @default.
- W2045562899 cites W1994543234 @default.
- W2045562899 cites W1994554610 @default.
- W2045562899 cites W1994609866 @default.
- W2045562899 cites W1996537516 @default.
- W2045562899 cites W1996574563 @default.
- W2045562899 cites W1997809258 @default.
- W2045562899 cites W1999519884 @default.
- W2045562899 cites W2003232469 @default.
- W2045562899 cites W2003437650 @default.
- W2045562899 cites W2004898220 @default.
- W2045562899 cites W2005564177 @default.
- W2045562899 cites W2007748456 @default.
- W2045562899 cites W2008774076 @default.
- W2045562899 cites W2010792749 @default.
- W2045562899 cites W2010942481 @default.
- W2045562899 cites W2013370441 @default.
- W2045562899 cites W2013395798 @default.
- W2045562899 cites W2015025117 @default.
- W2045562899 cites W2015541518 @default.
- W2045562899 cites W2015708455 @default.
- W2045562899 cites W2016447615 @default.
- W2045562899 cites W2016772432 @default.
- W2045562899 cites W2017560509 @default.
- W2045562899 cites W2019070574 @default.
- W2045562899 cites W2020068741 @default.
- W2045562899 cites W2020470831 @default.
- W2045562899 cites W2020925755 @default.
- W2045562899 cites W2021616998 @default.
- W2045562899 cites W2021946881 @default.
- W2045562899 cites W2022554048 @default.
- W2045562899 cites W2023357335 @default.
- W2045562899 cites W2023494424 @default.
- W2045562899 cites W2025341690 @default.
- W2045562899 cites W2025607561 @default.
- W2045562899 cites W2026644088 @default.
- W2045562899 cites W2028545299 @default.
- W2045562899 cites W2034209605 @default.
- W2045562899 cites W2034430748 @default.
- W2045562899 cites W2034745336 @default.
- W2045562899 cites W2034968148 @default.
- W2045562899 cites W2035833161 @default.
- W2045562899 cites W2037904566 @default.
- W2045562899 cites W2038070292 @default.
- W2045562899 cites W2040665951 @default.
- W2045562899 cites W2041555699 @default.
- W2045562899 cites W2041834559 @default.
- W2045562899 cites W2043289595 @default.
- W2045562899 cites W2044136517 @default.
- W2045562899 cites W2044918250 @default.
- W2045562899 cites W2045219086 @default.
- W2045562899 cites W2045317765 @default.
- W2045562899 cites W2045367317 @default.
- W2045562899 cites W2045508263 @default.