Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045571505> ?p ?o ?g. }
- W2045571505 endingPage "71" @default.
- W2045571505 startingPage "63" @default.
- W2045571505 abstract "PrP, the principal factor modulating resistance/susceptibility to transmissible spongiform encephalopathies, is a well conserved protein bearing strong phylogenetic information, in spite of its relatively short sequence. The construction of the PrP tree allows inferring the probable ancestral sequence for Bovidae where variants were recorded. This ancestral PrP sequence is constituted by a series of 5 octa-repeats, 3 alpha-helices and 2 beta-strands which combines together to form an antiparallel beta-sheet. The appearance of a 6(th) octa-repeat in the Bovinae ancestor during the evolution of Cetartiodactyla is discussed. Additionally, the variation of the substitution rates of amino acids along the sequence revealed that the sites associated to resistance/susceptibility to TSE are mostly located in conservative regions, including alpha-helices and beta-strands. The composition of most variants very sensitive to TSE in sheep and human corresponds to derived sequences compared to the Eutherian ancestor. However, a homozygous resistant variant in sheep differs from the ancestral state." @default.
- W2045571505 created "2016-06-24" @default.
- W2045571505 creator A5016090058 @default.
- W2045571505 creator A5020737897 @default.
- W2045571505 creator A5082653008 @default.
- W2045571505 creator A5090558940 @default.
- W2045571505 date "2009-01-01" @default.
- W2045571505 modified "2023-10-12" @default.
- W2045571505 title "Polymorphism of the Prion Protein in Mammals: A Phylogenetic Approach" @default.
- W2045571505 cites W1591865817 @default.
- W2045571505 cites W1841689210 @default.
- W2045571505 cites W1964212731 @default.
- W2045571505 cites W1964249554 @default.
- W2045571505 cites W1981569310 @default.
- W2045571505 cites W1984830025 @default.
- W2045571505 cites W1985150889 @default.
- W2045571505 cites W1997716214 @default.
- W2045571505 cites W2014748329 @default.
- W2045571505 cites W2025546736 @default.
- W2045571505 cites W2030332733 @default.
- W2045571505 cites W2057579163 @default.
- W2045571505 cites W205890104 @default.
- W2045571505 cites W2075789718 @default.
- W2045571505 cites W2076146345 @default.
- W2045571505 cites W2088012365 @default.
- W2045571505 cites W2091165070 @default.
- W2045571505 cites W2095494728 @default.
- W2045571505 cites W2101671848 @default.
- W2045571505 cites W2103352856 @default.
- W2045571505 cites W2133876637 @default.
- W2045571505 cites W2137295513 @default.
- W2045571505 cites W2144766007 @default.
- W2045571505 cites W2146396346 @default.
- W2045571505 cites W2147854065 @default.
- W2045571505 cites W2148130200 @default.
- W2045571505 cites W2156964954 @default.
- W2045571505 cites W2160679095 @default.
- W2045571505 cites W3199943451 @default.
- W2045571505 doi "https://doi.org/10.2174/187221509787236156" @default.
- W2045571505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19149740" @default.
- W2045571505 hasPublicationYear "2009" @default.
- W2045571505 type Work @default.
- W2045571505 sameAs 2045571505 @default.
- W2045571505 citedByCount "9" @default.
- W2045571505 countsByYear W20455715052012 @default.
- W2045571505 countsByYear W20455715052013 @default.
- W2045571505 countsByYear W20455715052014 @default.
- W2045571505 countsByYear W20455715052017 @default.
- W2045571505 countsByYear W20455715052021 @default.
- W2045571505 crossrefType "journal-article" @default.
- W2045571505 hasAuthorship W2045571505A5016090058 @default.
- W2045571505 hasAuthorship W2045571505A5020737897 @default.
- W2045571505 hasAuthorship W2045571505A5082653008 @default.
- W2045571505 hasAuthorship W2045571505A5090558940 @default.
- W2045571505 hasConcept C104317684 @default.
- W2045571505 hasConcept C115260700 @default.
- W2045571505 hasConcept C121332964 @default.
- W2045571505 hasConcept C142089489 @default.
- W2045571505 hasConcept C166957645 @default.
- W2045571505 hasConcept C167625842 @default.
- W2045571505 hasConcept C193252679 @default.
- W2045571505 hasConcept C197583594 @default.
- W2045571505 hasConcept C2778112365 @default.
- W2045571505 hasConcept C2780422015 @default.
- W2045571505 hasConcept C45484198 @default.
- W2045571505 hasConcept C54355233 @default.
- W2045571505 hasConcept C62520636 @default.
- W2045571505 hasConcept C78458016 @default.
- W2045571505 hasConcept C86803240 @default.
- W2045571505 hasConcept C90132467 @default.
- W2045571505 hasConcept C95457728 @default.
- W2045571505 hasConceptScore W2045571505C104317684 @default.
- W2045571505 hasConceptScore W2045571505C115260700 @default.
- W2045571505 hasConceptScore W2045571505C121332964 @default.
- W2045571505 hasConceptScore W2045571505C142089489 @default.
- W2045571505 hasConceptScore W2045571505C166957645 @default.
- W2045571505 hasConceptScore W2045571505C167625842 @default.
- W2045571505 hasConceptScore W2045571505C193252679 @default.
- W2045571505 hasConceptScore W2045571505C197583594 @default.
- W2045571505 hasConceptScore W2045571505C2778112365 @default.
- W2045571505 hasConceptScore W2045571505C2780422015 @default.
- W2045571505 hasConceptScore W2045571505C45484198 @default.
- W2045571505 hasConceptScore W2045571505C54355233 @default.
- W2045571505 hasConceptScore W2045571505C62520636 @default.
- W2045571505 hasConceptScore W2045571505C78458016 @default.
- W2045571505 hasConceptScore W2045571505C86803240 @default.
- W2045571505 hasConceptScore W2045571505C90132467 @default.
- W2045571505 hasConceptScore W2045571505C95457728 @default.
- W2045571505 hasIssue "1" @default.
- W2045571505 hasLocation W20455715051 @default.
- W2045571505 hasLocation W20455715052 @default.
- W2045571505 hasLocation W20455715053 @default.
- W2045571505 hasLocation W20455715054 @default.
- W2045571505 hasLocation W20455715055 @default.
- W2045571505 hasLocation W20455715056 @default.
- W2045571505 hasOpenAccess W2045571505 @default.
- W2045571505 hasPrimaryLocation W20455715051 @default.
- W2045571505 hasRelatedWork W1797343337 @default.