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• W2045574002 abstract "ABSTRACT The absence of endogenous mouse mammary tumor viruses (MMTVs) in the congenic mouse strain, BALB/ Mtv -null, restricts the early steps of exogenous C3H MMTV infection, preventing the superantigen (Sag) response and mammary tumorigenesis. Here we demonstrate that BALB/ Mtv -null mice also resist tumor induction by FM MMTV, which encodes a stronger Sag compared to C3H MMTV. In contrast to infections with C3H MMTV, Mtv -null mice show FM-MMTV Sag-specific responses comparable to those observed in susceptible BALB/c mice. Neither virus shows significant replication in the spleen or mammary gland. Thus, Mtv -null mice restrict MMTV replication and mammary tumorigenesis even after a robust Sag response." @default.
• W2045574002 created "2016-06-24" @default.
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• W2045574002 date "2009-01-01" @default.
• W2045574002 modified "2023-09-23" @default.
• W2045574002 title "BALB/ <i>Mtv</i> -Null Mice Responding to Strong Mouse Mammary Tumor Virus Superantigens Restrict Mammary Tumorigenesis" @default.
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• W2045574002 doi "https://doi.org/10.1128/jvi.01374-08" @default.
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