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- W2045574906 abstract "(−)-Paroxetine hydrochloride was produced asymmetrically in seven steps starting from 4-fluorobenzaldehyde. The stereocenter at C-4 was initially set through desymmetrization of glutaric acid bis methyl ester 4 by PLE hydrolysis. A unique one-pot reduction–alkylation procedure was then developed to provide entry to lactam 2 with the appropriate absolute stereochemistry." @default.
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- W2045574906 title "Asymmetric synthesis of (−)-paroxetine using PLE hydrolysis" @default.
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- W2045574906 doi "https://doi.org/10.1016/s0040-4039(00)00942-4" @default.
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