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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045578045> ?p ?o ?g. }

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• W2045578045 startingPage "1749" @default.
• W2045578045 abstract "OBJECTIVE: The purpose of this study was to evaluate the efficacy and safety of a single nightly 500-mg Rowasa (mesalamine) suppository as maintenance therapy for patients with ulcerative proctitis in remission. METHODS: In this 24-month, multicenter, double-blind trial, 65 patients with ulcerative proctitis in clinical and endoscopic remission were randomized to receive either a single nightly 500-mg rectal mesalamine (Rowasa) suppository or matching placebo as sole therapy. Efficacy was assessed by time to relapse (defined as rectal bleeding or increase in stool frequency for ≥1 wk and active inflammation upon endoscopy). RESULTS: Mean time to relapse was 453.4 days for mesalamine-treated patients and 158.0 days for placebo-treated patients. Survival analysis demonstrated that time to relapse was significantly greater for mesalamine-treated patients than for placebo-treated patients (p < 0.001). In addition, at both 12 and 24 months, the proportion of placebo-treated patients (86% at 12 months and 89% at 24 months) who relapsed was significantly (p≤ 0.001) greater than mesalamine-treated patients (32% and 46%, respectively). No statistically significant differences occurred between treatment groups in the reporting of any particular adverse event or the number of patients reporting adverse events. CONCLUSIONS: The results demonstrate that mesalamine suppositories are efficacious, well tolerated, and safe for the long-term maintenance of remission of ulcerative proctitis." @default.
• W2045578045 created "2016-06-24" @default.
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• W2045578045 date "2000-07-01" @default.
• W2045578045 modified "2023-10-16" @default.
• W2045578045 title "Long-Term Use of Mesalamine (Rowasa) Suppositories in Remission Maintenance of Ulcerative Proctitis" @default.
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• W2045578045 doi "https://doi.org/10.1111/j.1572-0241.2000.02185.x" @default.
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