Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045578618> ?p ?o ?g. }
- W2045578618 endingPage "1000" @default.
- W2045578618 startingPage "997" @default.
- W2045578618 abstract "5-Hydroxytryptamine (5-HT) is an important neurotransmitter mediating many aspects of cognition and behaviour. One psychology in which 5-HT plays an important role is impulsive responding. Recently, we have demonstrated that variation in an aspect of impulsive behaviour, namely delayed gratification, has a clear genetic contribution. Here, we examined the neurobiological relevance of a recently discovered single nucleotide polymorphism (SNP) in the murine gene tryptophan hydroxylase (mTph2) by analysing extracellular levels of 5-HT in medial prefrontal cortex (mPFC) and ventral striatum (VS), key brain regions for impulsive behaviours. The allelic variants were associated with systematic effects on baseline 5-HT efflux in the mPFC and VS. We then went on to examine whether the mTph2 allelic variants gave rise to differences in impulsive behaviour. However, the mTph2 genotype, and therefore presumably baseline brain levels of 5-HT, did not predict impulsive choice, as indexed by sensitivity to delayed reinforcement. Consequently, the data do not support a role for the mTph2 C1473G polymorphism on this aspect of impulsive behaviour. Instead, they indicate that perturbations of the 5-HT system via heritable traits may have differential consequences for qualitatively distinct aspects of impulsive behaviour." @default.
- W2045578618 created "2016-06-24" @default.
- W2045578618 creator A5000445902 @default.
- W2045578618 creator A5002957093 @default.
- W2045578618 creator A5017054906 @default.
- W2045578618 creator A5045837411 @default.
- W2045578618 creator A5050922048 @default.
- W2045578618 creator A5064745330 @default.
- W2045578618 date "2005-08-01" @default.
- W2045578618 modified "2023-10-09" @default.
- W2045578618 title "An mTph2 SNP gives rise to alterations in extracellular 5-HT levels, but not in performance on a delayed-reinforcement task" @default.
- W2045578618 cites W1545592082 @default.
- W2045578618 cites W1973466311 @default.
- W2045578618 cites W1976503128 @default.
- W2045578618 cites W1977947329 @default.
- W2045578618 cites W1978443369 @default.
- W2045578618 cites W1991271750 @default.
- W2045578618 cites W2003758179 @default.
- W2045578618 cites W2010687330 @default.
- W2045578618 cites W2018140837 @default.
- W2045578618 cites W2019675253 @default.
- W2045578618 cites W2021190392 @default.
- W2045578618 cites W2029111326 @default.
- W2045578618 cites W2033371591 @default.
- W2045578618 cites W2059419081 @default.
- W2045578618 cites W2062049551 @default.
- W2045578618 cites W2070922860 @default.
- W2045578618 cites W2073158960 @default.
- W2045578618 cites W2074140874 @default.
- W2045578618 cites W2075104305 @default.
- W2045578618 cites W2076368041 @default.
- W2045578618 cites W2077505677 @default.
- W2045578618 cites W2078529050 @default.
- W2045578618 cites W2086172007 @default.
- W2045578618 cites W2087856744 @default.
- W2045578618 cites W2088842558 @default.
- W2045578618 cites W2089217485 @default.
- W2045578618 cites W2090868889 @default.
- W2045578618 cites W2092446347 @default.
- W2045578618 cites W2093536661 @default.
- W2045578618 cites W2124106518 @default.
- W2045578618 cites W2126092103 @default.
- W2045578618 cites W2126155954 @default.
- W2045578618 cites W2141434652 @default.
- W2045578618 cites W2162196924 @default.
- W2045578618 cites W2168722817 @default.
- W2045578618 cites W4229747958 @default.
- W2045578618 cites W4375905816 @default.
- W2045578618 doi "https://doi.org/10.1111/j.1460-9568.2005.04265.x" @default.
- W2045578618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16115223" @default.
- W2045578618 hasPublicationYear "2005" @default.
- W2045578618 type Work @default.
- W2045578618 sameAs 2045578618 @default.
- W2045578618 citedByCount "18" @default.
- W2045578618 countsByYear W20455786182012 @default.
- W2045578618 countsByYear W20455786182014 @default.
- W2045578618 countsByYear W20455786182016 @default.
- W2045578618 countsByYear W20455786182018 @default.
- W2045578618 crossrefType "journal-article" @default.
- W2045578618 hasAuthorship W2045578618A5000445902 @default.
- W2045578618 hasAuthorship W2045578618A5002957093 @default.
- W2045578618 hasAuthorship W2045578618A5017054906 @default.
- W2045578618 hasAuthorship W2045578618A5045837411 @default.
- W2045578618 hasAuthorship W2045578618A5050922048 @default.
- W2045578618 hasAuthorship W2045578618A5064745330 @default.
- W2045578618 hasBestOaLocation W20455786181 @default.
- W2045578618 hasConcept C104317684 @default.
- W2045578618 hasConcept C135763542 @default.
- W2045578618 hasConcept C138496976 @default.
- W2045578618 hasConcept C139275648 @default.
- W2045578618 hasConcept C153209595 @default.
- W2045578618 hasConcept C15744967 @default.
- W2045578618 hasConcept C169760540 @default.
- W2045578618 hasConcept C169900460 @default.
- W2045578618 hasConcept C170493617 @default.
- W2045578618 hasConcept C180754005 @default.
- W2045578618 hasConcept C2775864247 @default.
- W2045578618 hasConcept C2780319597 @default.
- W2045578618 hasConcept C2781195155 @default.
- W2045578618 hasConcept C54355233 @default.
- W2045578618 hasConcept C86803240 @default.
- W2045578618 hasConceptScore W2045578618C104317684 @default.
- W2045578618 hasConceptScore W2045578618C135763542 @default.
- W2045578618 hasConceptScore W2045578618C138496976 @default.
- W2045578618 hasConceptScore W2045578618C139275648 @default.
- W2045578618 hasConceptScore W2045578618C153209595 @default.
- W2045578618 hasConceptScore W2045578618C15744967 @default.
- W2045578618 hasConceptScore W2045578618C169760540 @default.
- W2045578618 hasConceptScore W2045578618C169900460 @default.
- W2045578618 hasConceptScore W2045578618C170493617 @default.
- W2045578618 hasConceptScore W2045578618C180754005 @default.
- W2045578618 hasConceptScore W2045578618C2775864247 @default.
- W2045578618 hasConceptScore W2045578618C2780319597 @default.
- W2045578618 hasConceptScore W2045578618C2781195155 @default.
- W2045578618 hasConceptScore W2045578618C54355233 @default.
- W2045578618 hasConceptScore W2045578618C86803240 @default.
- W2045578618 hasIssue "4" @default.
- W2045578618 hasLocation W20455786181 @default.