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• W2045578765 abstract "The immune system includes CD4+ regulatory T (Treg) cells that play a role in self-tolerance and demonstrate functional variations that govern immune responses. HHV-6 is an important immunosuppressive virus that completely replicates in vivo and in vitro in only CD4+ T cells. However, there have been no reports of the specific T-cell subpopulation that permits the replication of this virus. Here, we evaluated the infectivity of HHV-6 to specific T-cell populations such as CD4+CD25high, which includes the majority of Treg cells, and CD4+CD25–. These cells were isolated from peripheral blood and then expanded. The expanded cell fractions were then infected with the HHV-6 variant B strain, and the spreads of infected cells were evaluated by immunofluorescence. Viral growth was also quantified by real-time PCR. The effects of virus infection on cytokine production from these T-cell subsets were examined using ELISA. Our results revealed that both these fractions permitted complete HHV-6 replication. Virus infection enhanced the production of both Th1- and Th2-type cytokines from CD4+CD25– T cells; however, only Th2-type cytokine release was augmented from viral-infected CD4+CD25high T cells. Further, while virus-infected CD4+CD25high T cells shift their antiviral immunity toward Th2 dominance by producing IL-10, the role of virus-infected CD4+CD25– T cells remains obscure." @default.
• W2045578765 created "2016-06-24" @default.
• W2045578765 creator A5060448276 @default.
• W2045578765 creator A5063188062 @default.
• W2045578765 date "2007-10-01" @default.
• W2045578765 modified "2023-10-02" @default.
• W2045578765 title "Human Herpesvirus 6 Infection of CD4⁺T-Cell Subsets" @default.
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• W2045578765 doi "https://doi.org/10.1111/j.1348-0421.2007.tb03996.x" @default.
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