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• W2045581644 startingPage "1" @default.
• W2045581644 abstract "The pleiotropic activity of oestrogens and their mechanism of action via their binding to the two oestrogen receptors alpha (ER alpha) and beta (ER beta) subtypes in the different tissues where oestrogens exert their action have been briefly described. The fate of these compounds trapped into different galenic forms is discussed with regard to their therapeutic applications. Firstly, the advantages and disadvantages of the different forms (pills, i.v. forms and transdermal patches) used in contraception are compared. Secondly, the therapeutic use of formulated oestrogens for the post-menopausal hormone replacement therapy (HRT) is analysed through the various results obtained in different trials. The link between HRT and the risks of breast cancer and cardiovascular disease is underlined. Finally, comparing the activity of selective oestrogen receptor modulators such as tamoxifen and pure anti-oestrogens such as RU58668 and ICI182780, we analysed the reasons leading to the need for a tumor targeting of the latters, but not of the former for the treatment of oestrogen-dependent breast cancer. Different injectable and biodegradable formulations, that lead to a remarkable anti-tumor efficiency in xenografts, have been recently developed and we believe that they may represent promising new administration ways of added therapeutic values for anti-oestrogens. Such devices could be extended to the delivery of other anti-cancer drugs with more aggressive activities than anti-oestrogens." @default.
• W2045581644 created "2016-06-24" @default.
• W2045581644 creator A5015452989 @default.
• W2045581644 creator A5028675960 @default.
• W2045581644 creator A5047564616 @default.
• W2045581644 creator A5070280534 @default.
• W2045581644 date "2004-09-01" @default.
• W2045581644 modified "2023-10-01" @default.
• W2045581644 title "Drug delivery systems for oestrogenic hormones and antagonists: the need for selective targeting in estradiol-dependent cancers" @default.
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