FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045584725> ?p ?o ?g. }

• W2045584725 endingPage "507" @default.
• W2045584725 startingPage "499" @default.
• W2045584725 abstract "Duchenne muscular dystrophy (DMD), a severe X-linked recessive disorder which results in progressive muscle degeneration, is due to a lack of dystrophin, a membrane cytoskeletal protein. An approach to treatment is to compensate for dystrophin loss with utrophin, another cytoskeletal protein with over 80% homology with dystrophin. Utrophin is expressed, at the neuromuscular junction, in normal and DMD muscles and there is evidence that it may perform the same cellular functions as dystrophin. So, the identification of molecules or drugs that could up-regulate utrophin is a very important goal for therapy. We show that in adult normal and mdx mice (an animal model of Duchenne myopathy) treated with l-arginine, the substrate of nitric oxide synthase (NOS), a pool of utrophin localized at the membrane appeared and increased, respectively. In normal and mdx myotubes in culture, l-arginine, nitric oxide (NO), or hydroxyurea increased utrophin levels and enhanced its membrane localization. This effect did not occur with d-arginine, showing the involvement of NOS in this process. The NO-induced increase in utrophin was prevented by oxadiazolo-quinoxalin-1-one, an inhibitor of a soluble guanylate cyclase implicated in NO effects. These results open the way to a potential treatment for Duchenne and Becker dystrophies." @default.
• W2045584725 created "2016-06-24" @default.
• W2045584725 creator A5019635621 @default.
• W2045584725 creator A5057031880 @default.
• W2045584725 creator A5075573650 @default.
• W2045584725 creator A5080876355 @default.
• W2045584725 creator A5083593653 @default.
• W2045584725 creator A5084855822 @default.
• W2045584725 date "1999-12-01" @default.
• W2045584725 modified "2023-10-18" @default.
• W2045584725 title "Nitric Oxide and l-Arginine Cause an Accumulation of Utrophin at the Sarcolemma: A Possible Compensation for Dystrophin Loss in Duchenne Muscular Dystrophy" @default.
• W2045584725 cites W1521447037 @default.
• W2045584725 cites W1525849227 @default.
• W2045584725 cites W1581147589 @default.
• W2045584725 cites W1967391351 @default.
• W2045584725 cites W1968672206 @default.
• W2045584725 cites W1972049148 @default.
• W2045584725 cites W1972568955 @default.
• W2045584725 cites W1977394169 @default.
• W2045584725 cites W1983555241 @default.
• W2045584725 cites W1987722398 @default.
• W2045584725 cites W1998263954 @default.
• W2045584725 cites W2001458618 @default.
• W2045584725 cites W2003922674 @default.
• W2045584725 cites W2023532051 @default.
• W2045584725 cites W2026728314 @default.
• W2045584725 cites W2038685361 @default.
• W2045584725 cites W2041741506 @default.
• W2045584725 cites W2044634543 @default.
• W2045584725 cites W2054963293 @default.
• W2045584725 cites W2055224057 @default.
• W2045584725 cites W2058078030 @default.
• W2045584725 cites W2059155059 @default.
• W2045584725 cites W2062746471 @default.
• W2045584725 cites W2064217024 @default.
• W2045584725 cites W2065182000 @default.
• W2045584725 cites W2066180106 @default.
• W2045584725 cites W2068018243 @default.
• W2045584725 cites W2068871150 @default.
• W2045584725 cites W2083990885 @default.
• W2045584725 cites W2091202354 @default.
• W2045584725 cites W2091212285 @default.
• W2045584725 cites W2093118511 @default.
• W2045584725 cites W2101794818 @default.
• W2045584725 cites W2103944414 @default.
• W2045584725 cites W2131678910 @default.
• W2045584725 cites W2140477606 @default.
• W2045584725 cites W2313825712 @default.
• W2045584725 cites W2338369943 @default.
• W2045584725 doi "https://doi.org/10.1006/nbdi.1999.0256" @default.
• W2045584725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10600405" @default.
• W2045584725 hasPublicationYear "1999" @default.
• W2045584725 type Work @default.
• W2045584725 sameAs 2045584725 @default.
• W2045584725 citedByCount "60" @default.
• W2045584725 countsByYear W20455847252012 @default.
• W2045584725 countsByYear W20455847252013 @default.
• W2045584725 countsByYear W20455847252014 @default.
• W2045584725 countsByYear W20455847252015 @default.
• W2045584725 countsByYear W20455847252017 @default.
• W2045584725 countsByYear W20455847252018 @default.
• W2045584725 countsByYear W20455847252020 @default.
• W2045584725 countsByYear W20455847252021 @default.
• W2045584725 countsByYear W20455847252022 @default.
• W2045584725 crossrefType "journal-article" @default.
• W2045584725 hasAuthorship W2045584725A5019635621 @default.
• W2045584725 hasAuthorship W2045584725A5057031880 @default.
• W2045584725 hasAuthorship W2045584725A5075573650 @default.
• W2045584725 hasAuthorship W2045584725A5080876355 @default.
• W2045584725 hasAuthorship W2045584725A5083593653 @default.
• W2045584725 hasAuthorship W2045584725A5084855822 @default.
• W2045584725 hasConcept C126322002 @default.
• W2045584725 hasConcept C134018914 @default.
• W2045584725 hasConcept C185592680 @default.
• W2045584725 hasConcept C199096232 @default.
• W2045584725 hasConcept C207200792 @default.
• W2045584725 hasConcept C2777622882 @default.
• W2045584725 hasConcept C2778943923 @default.
• W2045584725 hasConcept C2779030066 @default.
• W2045584725 hasConcept C2780394045 @default.
• W2045584725 hasConcept C519581460 @default.
• W2045584725 hasConcept C71924100 @default.
• W2045584725 hasConcept C78343239 @default.
• W2045584725 hasConcept C86803240 @default.
• W2045584725 hasConcept C95444343 @default.
• W2045584725 hasConceptScore W2045584725C126322002 @default.
• W2045584725 hasConceptScore W2045584725C134018914 @default.
• W2045584725 hasConceptScore W2045584725C185592680 @default.
• W2045584725 hasConceptScore W2045584725C199096232 @default.
• W2045584725 hasConceptScore W2045584725C207200792 @default.
• W2045584725 hasConceptScore W2045584725C2777622882 @default.
• W2045584725 hasConceptScore W2045584725C2778943923 @default.
• W2045584725 hasConceptScore W2045584725C2779030066 @default.
• W2045584725 hasConceptScore W2045584725C2780394045 @default.
• W2045584725 hasConceptScore W2045584725C519581460 @default.
• W2045584725 hasConceptScore W2045584725C71924100 @default.
• W2045584725 hasConceptScore W2045584725C78343239 @default.
• W2045584725 hasConceptScore W2045584725C86803240 @default.

• next