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• W2045585923 startingPage "e0124177" @default.
• W2045585923 abstract "Syphilis is a globally occurring venereal disease, and its infection is propagated through sexual contact. The causative agent of syphilis, Treponema pallidum ssp. pallidum, a Gram-negative sphirochaete, is an obligate human parasite. Genome of T. pallidum ssp. pallidum SS14 strain (RefSeq NC_010741.1) encodes 1,027 proteins, of which 444 proteins are known as hypothetical proteins (HPs), i.e., proteins of unknown functions. Here, we performed functional annotation of HPs of T. pallidum ssp. pallidum using various database, domain architecture predictors, protein function annotators and clustering tools. We have analyzed the sequences of 444 HPs of T. pallidum ssp. pallidum and subsequently predicted the function of 207 HPs with a high level of confidence. However, functions of 237 HPs are predicted with less accuracy. We found various enzymes, transporters, binding proteins in the annotated group of HPs that may be possible molecular targets, facilitating for the survival of pathogen. Our comprehensive analysis helps to understand the mechanism of pathogenesis to provide many novel potential therapeutic interventions." @default.
• W2045585923 created "2016-06-24" @default.
• W2045585923 creator A5050530317 @default.
• W2045585923 creator A5077513922 @default.
• W2045585923 creator A5087775910 @default.
• W2045585923 date "2015-04-20" @default.
• W2045585923 modified "2023-10-18" @default.
• W2045585923 title "Identification of Functional Candidates amongst Hypothetical Proteins of Treponema pallidum ssp. pallidum" @default.
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• W2045585923 doi "https://doi.org/10.1371/journal.pone.0124177" @default.
• W2045585923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5951579" @default.
• W2045585923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29758067" @default.
• W2045585923 hasPublicationYear "2015" @default.
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