FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045586824> ?p ?o ?g. }

• W2045586824 endingPage "S3" @default.
• W2045586824 startingPage "943" @default.
• W2045586824 abstract "The C–C chemokine receptor CCR5 in humans and rhesus macaques (Macaca mulatta) serves as the primary coreceptor for cellular entry by macrophagetropic strains of human immunodeficiency virus type 1 (HIV-1) and all reported strains of simian immunodeficiency virus (SIV) [1Alkhatib G Combadiere C Broder C Feng Y Kennedy P Murphy P et al.CC CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1.Science. 1996; 272 (96275693): 1955-1958Crossref PubMed Scopus (2393) Google Scholar, 2Chen Z Zhou P Ho DD Landau NR Marx PA Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry.J Virol. 1997; 71 (97213934): 2705-2714Crossref PubMed Google Scholar, 3Choe H Farzan M Sun Y Sullivan N Rollins B Ponath PD et al.The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.Cell. 1996; 85 (96270515): 1135-1148Abstract Full Text Full Text PDF PubMed Scopus (2037) Google Scholar, 4Deng H Liu R Ellmeier W Choe S Unutmaz D Burkhart M et al.Identification of a major co-receptor for primary isolates of HIV-1.Nature. 1996; 381 (96260017): 661-666Crossref PubMed Scopus (3127) Google Scholar, 5Dragic T Litwin V Allaway GP Martin SR Huang Y Nagashima KA et al.HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.Nature. 1996; 381 (96260018): 667-673Crossref PubMed Scopus (2756) Google Scholar, 6Marcon L Choe H Martin KA Farzan M Ponath PD Wu L et al.Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239.J Virol. 1997; 71 (97184592): 2522-2527PubMed Google Scholar]. Humans homozygous for a 32 bp deletion allele of CCR5, resulting in a null phenotype, are highly resistant to infection by HIV-1 [7Samson M Libert F Doranz BJ Rucker J Liesnard C Farber CM et al.Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.Nature. 1996; 382 (96345670): 722-725Crossref PubMed Scopus (2355) Google Scholar, 8Liu R Paxton W Choe S Ceradini D Martin S Horuk R et al.Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply exposed individuals to HIV-1 infection.Cell. 1996; 86 (96339434): 367-377Abstract Full Text Full Text PDF PubMed Scopus (2465) Google Scholar, 9Dean M Carrington M Winkler C Huttley GA Smith MW Allikmets R et al.Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study.Science. 1996; 273 (96386394): 1856-1862Crossref PubMed Scopus (2098) Google Scholar], prompting development of therapies and vaccines targeting CCR5. We now report a novel deletion allele of CCR5, with an allele frequency of 0.04, in sooty mangabey monkeys (Cercocebus torquatus atys), a natural host of SIV (SIVsmm) [[10]Fultz PN McClure HM Anderson DC Swenson RB Anand R Srinivasan A Isolation of a T-lymphotropic retrovirus from naturally infected sooty mangabey monkeys (Cercocebus atys).Proc Natl Acad Sci USA. 1986; 83 (86259775): 5286-5290Crossref PubMed Scopus (228) Google Scholar]. The mutant protein was not expressed at the cell surface and accordingly did not function as a viral coreceptor. Primary activated lymphocytes from mangabeys heterozygous for the deletion allele expressed significantly less CCR5 on the cell surface. Moreover, SIV seroprevalence and viremia were comparable among CCR5 heterozygotes and wild-type animals. Parallel evolution of CCR5-null alleles in humans and sooty mangabeys suggests that similar negative selection pressures have acted against CCR5, as would occur during epidemics of infectious agents that require CCR5 for pathogenesis. Sooty mangabeys bred to homozygosity for the deletion allele will be useful for experimental studies on the context-dependent role of CCR5 in host defense and microbial pathogenesis." @default.
• W2045586824 created "2016-06-24" @default.
• W2045586824 creator A5021689661 @default.
• W2045586824 creator A5029871990 @default.
• W2045586824 creator A5037980294 @default.
• W2045586824 creator A5047997604 @default.
• W2045586824 creator A5077357809 @default.
• W2045586824 creator A5081761664 @default.
• W2045586824 creator A5091596822 @default.
• W2045586824 date "1998-07-01" @default.
• W2045586824 modified "2023-10-16" @default.
• W2045586824 title "Parallel evolution of CCR5-null phenotypes in humans and in a natural host of simian immunodeficiency virus" @default.
• W2045586824 cites W1508657985 @default.
• W2045586824 cites W1578619398 @default.
• W2045586824 cites W1648671938 @default.
• W2045586824 cites W1965019797 @default.
• W2045586824 cites W1966559352 @default.
• W2045586824 cites W1966815718 @default.
• W2045586824 cites W1979975115 @default.
• W2045586824 cites W1981440980 @default.
• W2045586824 cites W1981644527 @default.
• W2045586824 cites W1986574361 @default.
• W2045586824 cites W1990679519 @default.
• W2045586824 cites W1996183144 @default.
• W2045586824 cites W2001424660 @default.
• W2045586824 cites W2007021820 @default.
• W2045586824 cites W2020164587 @default.
• W2045586824 cites W2026330341 @default.
• W2045586824 cites W2026444780 @default.
• W2045586824 cites W2033078023 @default.
• W2045586824 cites W2063587295 @default.
• W2045586824 cites W2090630729 @default.
• W2045586824 cites W2106513047 @default.
• W2045586824 cites W2142992633 @default.
• W2045586824 cites W2154121432 @default.
• W2045586824 cites W2156117117 @default.
• W2045586824 cites W2157713905 @default.
• W2045586824 cites W2164592489 @default.
• W2045586824 doi "https://doi.org/10.1016/s0960-9822(07)00378-8" @default.
• W2045586824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9707408" @default.
• W2045586824 hasPublicationYear "1998" @default.
• W2045586824 type Work @default.
• W2045586824 sameAs 2045586824 @default.
• W2045586824 citedByCount "36" @default.
• W2045586824 countsByYear W20455868242012 @default.
• W2045586824 countsByYear W20455868242014 @default.
• W2045586824 countsByYear W20455868242016 @default.
• W2045586824 countsByYear W20455868242017 @default.
• W2045586824 countsByYear W20455868242019 @default.
• W2045586824 countsByYear W20455868242022 @default.
• W2045586824 crossrefType "journal-article" @default.
• W2045586824 hasAuthorship W2045586824A5021689661 @default.
• W2045586824 hasAuthorship W2045586824A5029871990 @default.
• W2045586824 hasAuthorship W2045586824A5037980294 @default.
• W2045586824 hasAuthorship W2045586824A5047997604 @default.
• W2045586824 hasAuthorship W2045586824A5077357809 @default.
• W2045586824 hasAuthorship W2045586824A5081761664 @default.
• W2045586824 hasAuthorship W2045586824A5091596822 @default.
• W2045586824 hasBestOaLocation W20455868241 @default.
• W2045586824 hasConcept C104317684 @default.
• W2045586824 hasConcept C127716648 @default.
• W2045586824 hasConcept C12823836 @default.
• W2045586824 hasConcept C129470790 @default.
• W2045586824 hasConcept C13373296 @default.
• W2045586824 hasConcept C159047783 @default.
• W2045586824 hasConcept C170493617 @default.
• W2045586824 hasConcept C2522874641 @default.
• W2045586824 hasConcept C2776488936 @default.
• W2045586824 hasConcept C2777607303 @default.
• W2045586824 hasConcept C2777995582 @default.
• W2045586824 hasConcept C54355233 @default.
• W2045586824 hasConcept C86803240 @default.
• W2045586824 hasConcept C8891405 @default.
• W2045586824 hasConceptScore W2045586824C104317684 @default.
• W2045586824 hasConceptScore W2045586824C127716648 @default.
• W2045586824 hasConceptScore W2045586824C12823836 @default.
• W2045586824 hasConceptScore W2045586824C129470790 @default.
• W2045586824 hasConceptScore W2045586824C13373296 @default.
• W2045586824 hasConceptScore W2045586824C159047783 @default.
• W2045586824 hasConceptScore W2045586824C170493617 @default.
• W2045586824 hasConceptScore W2045586824C2522874641 @default.
• W2045586824 hasConceptScore W2045586824C2776488936 @default.
• W2045586824 hasConceptScore W2045586824C2777607303 @default.
• W2045586824 hasConceptScore W2045586824C2777995582 @default.
• W2045586824 hasConceptScore W2045586824C54355233 @default.
• W2045586824 hasConceptScore W2045586824C86803240 @default.
• W2045586824 hasConceptScore W2045586824C8891405 @default.
• W2045586824 hasIssue "16" @default.
• W2045586824 hasLocation W20455868241 @default.
• W2045586824 hasLocation W20455868242 @default.
• W2045586824 hasOpenAccess W2045586824 @default.
• W2045586824 hasPrimaryLocation W20455868241 @default.
• W2045586824 hasRelatedWork W1489355333 @default.
• W2045586824 hasRelatedWork W1604914713 @default.
• W2045586824 hasRelatedWork W2011837950 @default.
• W2045586824 hasRelatedWork W2041187342 @default.
• W2045586824 hasRelatedWork W205653339 @default.
• W2045586824 hasRelatedWork W2161164629 @default.

• next