FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045586837> ?p ?o ?g. }

• W2045586837 endingPage "976" @default.
• W2045586837 startingPage "967" @default.
• W2045586837 abstract "Preclinical in vivo research on inflammatory bowel diseases requires proper animal models and techniques allowing longitudinal monitoring of colonic inflammation without the need to kill animals. We evaluated colonoscopy and μ-positron emission tomography/computed tomography (μPET/CT) as monitoring tools in a model for chronic colitis in mice.Colitis was induced by adoptive transfer of CD4(+)CD25(-)CD62L(+) T cells in immunocompromised severe combined immunodeficient mice. Three study protocols were designed. In study 1, colonoscopy and µPET/CT were performed once, 4 weeks after transfer. In study 2 and study 3, colitis was sequentially followed up through colonoscopy (study 2) or colonoscopy plus µPET/CT (study 3). Each study included postmortem evaluation of colonic inflammation (macroscopy, microscopy, and myeloperoxidase activity).In study 1, both colonoscopy and µPET/CT detected colitis 4 weeks after transfer. Study 2 showed a gradual increase in colonoscopic score from week 2 (1.4 ± 0.6) to week 8 (6.0 ± 1.1). In study 3, colitis was detected 2 weeks after transfer by µPET/CT (2.0 ± 0.4) but not by colonoscopy, whereas both techniques detected inflammation 4 and 6 weeks after transfer. Colonoscopy correlated with µPET/CT (r = 0.812, 0.884, and 0.781, respectively) and with postmortem analyses in all 3 studies.Adoptive transfer of CD4(+)CD25(-)CD62L(+) T cells in severe combined immunodeficient mice results in a moderate chronic colitis. Evolution of colitis could be monitored over time by both colonoscopy and µPET/CT. µPET/CT seems to detect inflammation at an earlier time point than colonoscopy. Both techniques represent reliable and safe methods without the need to kill animals." @default.
• W2045586837 created "2016-06-24" @default.
• W2045586837 creator A5004021022 @default.
• W2045586837 creator A5010591676 @default.
• W2045586837 creator A5027563252 @default.
• W2045586837 creator A5028838249 @default.
• W2045586837 creator A5032128794 @default.
• W2045586837 creator A5041656258 @default.
• W2045586837 creator A5046582725 @default.
• W2045586837 creator A5050774304 @default.
• W2045586837 creator A5065375123 @default.
• W2045586837 creator A5083236320 @default.
• W2045586837 date "2013-04-01" @default.
• W2045586837 modified "2023-09-27" @default.
• W2045586837 title "Colonoscopy and µPET/CT are Valid Techniques to Monitor Inflammation in the Adoptive Transfer Colitis Model in Mice" @default.
• W2045586837 cites W1573487564 @default.
• W2045586837 cites W1967891755 @default.
• W2045586837 cites W1971065686 @default.
• W2045586837 cites W1971119469 @default.
• W2045586837 cites W1988975884 @default.
• W2045586837 cites W2002061924 @default.
• W2045586837 cites W2005699139 @default.
• W2045586837 cites W2025365647 @default.
• W2045586837 cites W2026264384 @default.
• W2045586837 cites W2035347939 @default.
• W2045586837 cites W2039967018 @default.
• W2045586837 cites W2042149494 @default.
• W2045586837 cites W2047962826 @default.
• W2045586837 cites W2053486923 @default.
• W2045586837 cites W2056953205 @default.
• W2045586837 cites W2067911439 @default.
• W2045586837 cites W2083568730 @default.
• W2045586837 cites W2096722578 @default.
• W2045586837 cites W2098733700 @default.
• W2045586837 cites W2108229642 @default.
• W2045586837 cites W2136910816 @default.
• W2045586837 cites W2137020032 @default.
• W2045586837 cites W2166839330 @default.
• W2045586837 cites W2168036150 @default.
• W2045586837 cites W2168524781 @default.
• W2045586837 cites W2170180772 @default.
• W2045586837 cites W297072994 @default.
• W2045586837 cites W4292198229 @default.
• W2045586837 doi "https://doi.org/10.1097/mib.0b013e3182802c7c" @default.
• W2045586837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23407045" @default.
• W2045586837 hasPublicationYear "2013" @default.
• W2045586837 type Work @default.
• W2045586837 sameAs 2045586837 @default.
• W2045586837 citedByCount "15" @default.
• W2045586837 countsByYear W20455868372014 @default.
• W2045586837 countsByYear W20455868372015 @default.
• W2045586837 countsByYear W20455868372016 @default.
• W2045586837 countsByYear W20455868372017 @default.
• W2045586837 countsByYear W20455868372018 @default.
• W2045586837 countsByYear W20455868372020 @default.
• W2045586837 countsByYear W20455868372021 @default.
• W2045586837 countsByYear W20455868372023 @default.
• W2045586837 crossrefType "journal-article" @default.
• W2045586837 hasAuthorship W2045586837A5004021022 @default.
• W2045586837 hasAuthorship W2045586837A5010591676 @default.
• W2045586837 hasAuthorship W2045586837A5027563252 @default.
• W2045586837 hasAuthorship W2045586837A5028838249 @default.
• W2045586837 hasAuthorship W2045586837A5032128794 @default.
• W2045586837 hasAuthorship W2045586837A5041656258 @default.
• W2045586837 hasAuthorship W2045586837A5046582725 @default.
• W2045586837 hasAuthorship W2045586837A5050774304 @default.
• W2045586837 hasAuthorship W2045586837A5065375123 @default.
• W2045586837 hasAuthorship W2045586837A5083236320 @default.
• W2045586837 hasConcept C121608353 @default.
• W2045586837 hasConcept C126322002 @default.
• W2045586837 hasConcept C126838900 @default.
• W2045586837 hasConcept C142724271 @default.
• W2045586837 hasConcept C203014093 @default.
• W2045586837 hasConcept C2775842073 @default.
• W2045586837 hasConcept C2775862500 @default.
• W2045586837 hasConcept C2776090121 @default.
• W2045586837 hasConcept C2776914184 @default.
• W2045586837 hasConcept C2778260677 @default.
• W2045586837 hasConcept C2778435480 @default.
• W2045586837 hasConcept C2779134260 @default.
• W2045586837 hasConcept C526805850 @default.
• W2045586837 hasConcept C71924100 @default.
• W2045586837 hasConcept C8891405 @default.
• W2045586837 hasConcept C90375314 @default.
• W2045586837 hasConcept C90924648 @default.
• W2045586837 hasConceptScore W2045586837C121608353 @default.
• W2045586837 hasConceptScore W2045586837C126322002 @default.
• W2045586837 hasConceptScore W2045586837C126838900 @default.
• W2045586837 hasConceptScore W2045586837C142724271 @default.
• W2045586837 hasConceptScore W2045586837C203014093 @default.
• W2045586837 hasConceptScore W2045586837C2775842073 @default.
• W2045586837 hasConceptScore W2045586837C2775862500 @default.
• W2045586837 hasConceptScore W2045586837C2776090121 @default.
• W2045586837 hasConceptScore W2045586837C2776914184 @default.
• W2045586837 hasConceptScore W2045586837C2778260677 @default.
• W2045586837 hasConceptScore W2045586837C2778435480 @default.
• W2045586837 hasConceptScore W2045586837C2779134260 @default.
• W2045586837 hasConceptScore W2045586837C526805850 @default.

• next