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- W2045587462 abstract "The monovalent monoclonal antibody onartuzumab (O) binds with the extracellular domain of the MET receptor in place of hepatocyte growth factor (HGF), thus blocking MET signaling. A phase 2 study combining O with erlotinib in pretreated NSCLC suggested that O could improve progression-free survival (PFS) and overall survival (OS) vs placebo (Pb) in MET IHC+ patients (pts). The GO27820 study was designed to investigate whether adding O would improve the efficacy of first-line platinum-doublet chemotherapy for sq NSCLC, a subtype with few treatment options." @default.
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- W2045587462 date "2014-11-01" @default.
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- W2045587462 title "Efficacy and Safety Results From a Phase 2, Placebo-Controlled Study of Onartuzumab Plus First-Line Platinum-Doublet Chemotherapy in Advanced Squamous-Cell Non-Small Cell Lung Cancer (sq NSCLC)" @default.
- W2045587462 doi "https://doi.org/10.1016/j.ijrobp.2014.08.215" @default.
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