FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045590003> ?p ?o ?g. }

• W2045590003 endingPage "709" @default.
• W2045590003 startingPage "704" @default.
• W2045590003 abstract "The performed investigations aimed on the identification of the anti-inflammatory principal of extracts of leaves of Sambucus ebulus L. (dwarf elder) in order to rationalize the traditional use of this plant for the treatment of chronically inflammatory diseases.Dwarf elder leaf extract was subjected to activity guided fractionation using inhibition of TNFα induced expression of vascular cell adhesion molecule 1 (VCAM-1) on the surface of human umbilical vein endothelial cells (HUVECs) as monitoring tool (positive control: parthenolide 10μM, VCAM-1 expression (% of control): 5.35±0.38%).Bio-guided isolation resulted in identification of ursolic acid as anti-inflammatory principal. Besides its inhibitory effects against TNFα induced expression of VCAM-1 (IC(50) 6.25 μM), ursolic acid inhibits also TNFα induced expression of ICAM-1 (IC(50) value between 3.13 and 6.25 μM) (positive control: parthenolide 10 μM, ICAM-1 expression (% of control): 38.89±16.6%). Toxic effects of ursolic acid on HUVECs can be drastically reduced using an enriched extract instead of the pure compound.Our findings suggest an additional mechanism of the anti-inflammatory activity of ursolic acid by demonstrating its ability to inhibit TNFα-stimulated expression of VCAM-1 and ICAM-1 and support the traditional use of extracts and preparations of Sambucus ebulus L., rich in ursolic acid, for the treatment of chronically inflammatory processes." @default.
• W2045590003 created "2016-06-24" @default.
• W2045590003 creator A5006946665 @default.
• W2045590003 creator A5009515093 @default.
• W2045590003 creator A5030888854 @default.
• W2045590003 creator A5030967054 @default.
• W2045590003 creator A5036203401 @default.
• W2045590003 creator A5050858669 @default.
• W2045590003 creator A5061026912 @default.
• W2045590003 creator A5063845621 @default.
• W2045590003 creator A5086577551 @default.
• W2045590003 date "2011-01-01" @default.
• W2045590003 modified "2023-09-24" @default.
• W2045590003 title "Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.)" @default.
• W2045590003 cites W1975370060 @default.
• W2045590003 cites W1982048172 @default.
• W2045590003 cites W1999693385 @default.
• W2045590003 cites W2007856143 @default.
• W2045590003 cites W2018557658 @default.
• W2045590003 cites W2034152593 @default.
• W2045590003 cites W2037742466 @default.
• W2045590003 cites W2045833952 @default.
• W2045590003 cites W2050082286 @default.
• W2045590003 cites W2055878807 @default.
• W2045590003 cites W2058911550 @default.
• W2045590003 cites W2059221492 @default.
• W2045590003 cites W2073803891 @default.
• W2045590003 cites W2076550642 @default.
• W2045590003 cites W2084865277 @default.
• W2045590003 cites W2088018829 @default.
• W2045590003 cites W2091205460 @default.
• W2045590003 cites W2093755380 @default.
• W2045590003 cites W2100581955 @default.
• W2045590003 cites W2102998091 @default.
• W2045590003 cites W2111205112 @default.
• W2045590003 cites W2119277091 @default.
• W2045590003 cites W2143828987 @default.
• W2045590003 doi "https://doi.org/10.1016/j.jep.2010.10.049" @default.
• W2045590003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3029555" @default.
• W2045590003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21040770" @default.
• W2045590003 hasPublicationYear "2011" @default.
• W2045590003 type Work @default.
• W2045590003 sameAs 2045590003 @default.
• W2045590003 citedByCount "42" @default.
• W2045590003 countsByYear W20455900032012 @default.
• W2045590003 countsByYear W20455900032013 @default.
• W2045590003 countsByYear W20455900032014 @default.
• W2045590003 countsByYear W20455900032015 @default.
• W2045590003 countsByYear W20455900032016 @default.
• W2045590003 countsByYear W20455900032017 @default.
• W2045590003 countsByYear W20455900032018 @default.
• W2045590003 countsByYear W20455900032019 @default.
• W2045590003 countsByYear W20455900032020 @default.
• W2045590003 countsByYear W20455900032021 @default.
• W2045590003 countsByYear W20455900032022 @default.
• W2045590003 crossrefType "journal-article" @default.
• W2045590003 hasAuthorship W2045590003A5006946665 @default.
• W2045590003 hasAuthorship W2045590003A5009515093 @default.
• W2045590003 hasAuthorship W2045590003A5030888854 @default.
• W2045590003 hasAuthorship W2045590003A5030967054 @default.
• W2045590003 hasAuthorship W2045590003A5036203401 @default.
• W2045590003 hasAuthorship W2045590003A5050858669 @default.
• W2045590003 hasAuthorship W2045590003A5061026912 @default.
• W2045590003 hasAuthorship W2045590003A5063845621 @default.
• W2045590003 hasAuthorship W2045590003A5086577551 @default.
• W2045590003 hasBestOaLocation W20455900031 @default.
• W2045590003 hasConcept C185592680 @default.
• W2045590003 hasConcept C190283241 @default.
• W2045590003 hasConcept C2779513101 @default.
• W2045590003 hasConcept C2779593781 @default.
• W2045590003 hasConcept C2780321935 @default.
• W2045590003 hasConcept C55493867 @default.
• W2045590003 hasConcept C556039675 @default.
• W2045590003 hasConcept C59822182 @default.
• W2045590003 hasConcept C71924100 @default.
• W2045590003 hasConcept C86803240 @default.
• W2045590003 hasConcept C98274493 @default.
• W2045590003 hasConceptScore W2045590003C185592680 @default.
• W2045590003 hasConceptScore W2045590003C190283241 @default.
• W2045590003 hasConceptScore W2045590003C2779513101 @default.
• W2045590003 hasConceptScore W2045590003C2779593781 @default.
• W2045590003 hasConceptScore W2045590003C2780321935 @default.
• W2045590003 hasConceptScore W2045590003C55493867 @default.
• W2045590003 hasConceptScore W2045590003C556039675 @default.
• W2045590003 hasConceptScore W2045590003C59822182 @default.
• W2045590003 hasConceptScore W2045590003C71924100 @default.
• W2045590003 hasConceptScore W2045590003C86803240 @default.
• W2045590003 hasConceptScore W2045590003C98274493 @default.
• W2045590003 hasIssue "2" @default.
• W2045590003 hasLocation W20455900031 @default.
• W2045590003 hasLocation W20455900032 @default.
• W2045590003 hasLocation W20455900033 @default.
• W2045590003 hasLocation W20455900034 @default.
• W2045590003 hasOpenAccess W2045590003 @default.
• W2045590003 hasPrimaryLocation W20455900031 @default.
• W2045590003 hasRelatedWork W2002461803 @default.
• W2045590003 hasRelatedWork W2045590003 @default.
• W2045590003 hasRelatedWork W2057948598 @default.

• next