FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045590505> ?p ?o ?g. }

• W2045590505 endingPage "278" @default.
• W2045590505 startingPage "269" @default.
• W2045590505 abstract "Systemic treatment with the noradrenaline neurotoxin DSP4 (N-[2-chloroethyl]-N-ethyl-2-bromobenzylamine; 7 days) led to a marked and quantitatively similar reduction (-80%) of endogenous noradrenaline, [3H]noradrenaline uptake in vitro and [3H]desipramine binding in the frontal cortex of adult rats. Inhibition of monoamine oxidase, and/or 1-dopa administration 1 week after DSP4 produced very small changes in brain noradrenaline and dopamine levels. These results are all consistent with the view that DSP4 produces an acute and selective degeneration of central noradrenaline nerve terminals. Pretreatment with the noradrenaline uptake blocker desipramine prevented the action of DSP4 almost completely, while treatment after DSP4 had minute effects on DSP4-induced reduction of endogenous noradrenaline and [3H]noradrenaline uptake. The data suggest that the irreversible neurotoxic actions of DSP4 are very rapid and largely complete within 0.5 h after DSP4 administration. Measurement of catecholamine turnover using monoamine oxidase inhibition by pargyline indicated an increased noradrenaline turnover in the remaining nerve terminals innervating cerebral cortex and hippocampus after DSP4, while dopamine turnover appeared to be decreased. Pretreatment with d-amphetamine and clonidine or subsequent treatment with oxotremorine were without effect on the DSP4-induced reductions of the regional brain noradrenaline levels. Morphine pretreatment was also ineffective, while repeated morphine administration after DSP4 produced a significant potentiation of the DSP4-induced noradrenaline depletion in the frontal cortex, cerebellum and the spinal cord. Pretreatment with the monoamine oxidase inhibitor pargyline led to a very pronounced counteraction of the DSP4-induced noradrenaline depletion in all brain regions analysed, in particular in the occipital cortex. The data suggest that morphine can potentiate the neurotoxic action of DSP4 while pargyline can counteract it." @default.
• W2045590505 created "2016-06-24" @default.
• W2045590505 creator A5031111159 @default.
• W2045590505 creator A5072053467 @default.
• W2045590505 date "1984-08-01" @default.
• W2045590505 modified "2023-10-17" @default.
• W2045590505 title "Pharmacological modifications of the neurotoxic action of the noradrenaline neurotoxin DSP4 on central noradrenaline neurons" @default.
• W2045590505 cites W1490334811 @default.
• W2045590505 cites W1965449120 @default.
• W2045590505 cites W1970404852 @default.
• W2045590505 cites W1979510857 @default.
• W2045590505 cites W1986425394 @default.
• W2045590505 cites W1996635788 @default.
• W2045590505 cites W1997024999 @default.
• W2045590505 cites W2021191754 @default.
• W2045590505 cites W2023325653 @default.
• W2045590505 cites W2029874805 @default.
• W2045590505 cites W2037236684 @default.
• W2045590505 cites W2039330551 @default.
• W2045590505 cites W2048508373 @default.
• W2045590505 cites W2054738957 @default.
• W2045590505 cites W2058049492 @default.
• W2045590505 cites W2061920047 @default.
• W2045590505 cites W2066389720 @default.
• W2045590505 cites W2069413548 @default.
• W2045590505 cites W2079364259 @default.
• W2045590505 cites W2081423244 @default.
• W2045590505 cites W2082378578 @default.
• W2045590505 cites W2086304497 @default.
• W2045590505 cites W2091837785 @default.
• W2045590505 cites W2092420580 @default.
• W2045590505 cites W2147608198 @default.
• W2045590505 cites W2161817459 @default.
• W2045590505 doi "https://doi.org/10.1016/0014-2999(84)90487-4" @default.
• W2045590505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6237924" @default.
• W2045590505 hasPublicationYear "1984" @default.
• W2045590505 type Work @default.
• W2045590505 sameAs 2045590505 @default.
• W2045590505 citedByCount "82" @default.
• W2045590505 countsByYear W20455905052013 @default.
• W2045590505 countsByYear W20455905052014 @default.
• W2045590505 countsByYear W20455905052015 @default.
• W2045590505 countsByYear W20455905052017 @default.
• W2045590505 countsByYear W20455905052018 @default.
• W2045590505 countsByYear W20455905052019 @default.
• W2045590505 countsByYear W20455905052021 @default.
• W2045590505 countsByYear W20455905052022 @default.
• W2045590505 crossrefType "journal-article" @default.
• W2045590505 hasAuthorship W2045590505A5031111159 @default.
• W2045590505 hasAuthorship W2045590505A5072053467 @default.
• W2045590505 hasConcept C126322002 @default.
• W2045590505 hasConcept C134018914 @default.
• W2045590505 hasConcept C181199279 @default.
• W2045590505 hasConcept C185592680 @default.
• W2045590505 hasConcept C2775894120 @default.
• W2045590505 hasConcept C2776024655 @default.
• W2045590505 hasConcept C2777067607 @default.
• W2045590505 hasConcept C2778468602 @default.
• W2045590505 hasConcept C2778514916 @default.
• W2045590505 hasConcept C2779177272 @default.
• W2045590505 hasConcept C2780250439 @default.
• W2045590505 hasConcept C2780358027 @default.
• W2045590505 hasConcept C2781161787 @default.
• W2045590505 hasConcept C513476851 @default.
• W2045590505 hasConcept C529278444 @default.
• W2045590505 hasConcept C55493867 @default.
• W2045590505 hasConcept C71924100 @default.
• W2045590505 hasConcept C86803240 @default.
• W2045590505 hasConceptScore W2045590505C126322002 @default.
• W2045590505 hasConceptScore W2045590505C134018914 @default.
• W2045590505 hasConceptScore W2045590505C181199279 @default.
• W2045590505 hasConceptScore W2045590505C185592680 @default.
• W2045590505 hasConceptScore W2045590505C2775894120 @default.
• W2045590505 hasConceptScore W2045590505C2776024655 @default.
• W2045590505 hasConceptScore W2045590505C2777067607 @default.
• W2045590505 hasConceptScore W2045590505C2778468602 @default.
• W2045590505 hasConceptScore W2045590505C2778514916 @default.
• W2045590505 hasConceptScore W2045590505C2779177272 @default.
• W2045590505 hasConceptScore W2045590505C2780250439 @default.
• W2045590505 hasConceptScore W2045590505C2780358027 @default.
• W2045590505 hasConceptScore W2045590505C2781161787 @default.
• W2045590505 hasConceptScore W2045590505C513476851 @default.
• W2045590505 hasConceptScore W2045590505C529278444 @default.
• W2045590505 hasConceptScore W2045590505C55493867 @default.
• W2045590505 hasConceptScore W2045590505C71924100 @default.
• W2045590505 hasConceptScore W2045590505C86803240 @default.
• W2045590505 hasIssue "3-4" @default.
• W2045590505 hasLocation W20455905051 @default.
• W2045590505 hasLocation W20455905052 @default.
• W2045590505 hasOpenAccess W2045590505 @default.
• W2045590505 hasPrimaryLocation W20455905051 @default.
• W2045590505 hasRelatedWork W1982449770 @default.
• W2045590505 hasRelatedWork W2016123453 @default.
• W2045590505 hasRelatedWork W2034423774 @default.
• W2045590505 hasRelatedWork W2034919334 @default.
• W2045590505 hasRelatedWork W2045590505 @default.
• W2045590505 hasRelatedWork W2089103608 @default.
• W2045590505 hasRelatedWork W2094492429 @default.

• next