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- W2045591069 endingPage "1005" @default.
- W2045591069 startingPage "981" @default.
- W2045591069 abstract "Genetic variation in DNA repair genes can modulate DNA repair capacity and may be related to cancer risk. However, study findings have been inconsistent. Inheritance of variant DNA repair genes is believed to influence individual susceptibility to the development of environmental cancer. Reliable knowledge on which the base excision repair (BER) sequence variants are associated with cancer risk would help elucidate the mechanism of cancer. Given that most of the previous studies had inadequate statistical power, we have conducted a systematic review on sequence variants in three important BER proteins. Here, we review published studies on the association between polymorphism in candidate BER genes and cancer risk. We focused on three key BER genes: 8-oxoguanine DNA glycosylase (OGG1), apurinic/apyrimidinic endonuclease (APE1/APEX1) and x-ray repair cross-complementing group 1 (XRCC1). These specific DNA repair genes were selected because of their critical role in maintaining genome integrity and, based on previous studies, suggesting that single-nucleotide polymorphisms (SNPs) in these genes have protective or deleterious effects on cancer risk. A total of 136 articles in the December 13, 2010 MEDLINE database (National Center for Biotechnology Information, http://www.ncbi.nlm.nih.gov/pubmed/) reporting polymorphism in OGG1, XRCC1 or APE1 genes were analyzed. Many of the reported SNPs had diverse association with specific human cancers. For example, there was a positive association between the OGG1 Ser326Cys variant and gastric and lung cancer, while the XRCC1Arg399Gln variant was associated with reduced cancer risk. Gene–environment interactions have been noted and may be important for colorectal and lung cancer risk and possibly other human cancers." @default.
- W2045591069 created "2016-06-24" @default.
- W2045591069 creator A5008585962 @default.
- W2045591069 creator A5025443512 @default.
- W2045591069 creator A5077443943 @default.
- W2045591069 date "2012-09-27" @default.
- W2045591069 modified "2023-10-07" @default.
- W2045591069 title "Impact of DNA polymorphisms in key DNA base excision repair proteins on cancer risk" @default.
- W2045591069 cites W1579504560 @default.
- W2045591069 cites W1717026628 @default.
- W2045591069 cites W1734082729 @default.
- W2045591069 cites W1923506064 @default.
- W2045591069 cites W1967894483 @default.
- W2045591069 cites W1972349989 @default.
- W2045591069 cites W1976514162 @default.
- W2045591069 cites W1977164609 @default.
- W2045591069 cites W1978377168 @default.
- W2045591069 cites W1979830645 @default.
- W2045591069 cites W1981049819 @default.
- W2045591069 cites W1983090368 @default.
- W2045591069 cites W1987459099 @default.
- W2045591069 cites W1988329942 @default.
- W2045591069 cites W1992261266 @default.
- W2045591069 cites W1993839684 @default.
- W2045591069 cites W1994792621 @default.
- W2045591069 cites W1996162873 @default.
- W2045591069 cites W2009243321 @default.
- W2045591069 cites W2009742891 @default.
- W2045591069 cites W2011371303 @default.
- W2045591069 cites W2012442261 @default.
- W2045591069 cites W2012602505 @default.
- W2045591069 cites W2014022790 @default.
- W2045591069 cites W2014188494 @default.
- W2045591069 cites W2020830322 @default.
- W2045591069 cites W2022958055 @default.
- W2045591069 cites W2023744038 @default.
- W2045591069 cites W2025544961 @default.
- W2045591069 cites W2027863473 @default.
- W2045591069 cites W2032399864 @default.
- W2045591069 cites W2034843156 @default.
- W2045591069 cites W2038558758 @default.
- W2045591069 cites W2043101565 @default.
- W2045591069 cites W2044538917 @default.
- W2045591069 cites W2048286734 @default.
- W2045591069 cites W2052510496 @default.
- W2045591069 cites W2059464136 @default.
- W2045591069 cites W2059972525 @default.
- W2045591069 cites W2061139019 @default.
- W2045591069 cites W2065457058 @default.
- W2045591069 cites W2067496062 @default.
- W2045591069 cites W2068323147 @default.
- W2045591069 cites W2073806145 @default.
- W2045591069 cites W2074754379 @default.
- W2045591069 cites W2077459815 @default.
- W2045591069 cites W2081685795 @default.
- W2045591069 cites W2081776606 @default.
- W2045591069 cites W2083682910 @default.
- W2045591069 cites W2089249138 @default.
- W2045591069 cites W2090366733 @default.
- W2045591069 cites W2091369898 @default.
- W2045591069 cites W2091492297 @default.
- W2045591069 cites W2092506359 @default.
- W2045591069 cites W2099609898 @default.
- W2045591069 cites W2100083322 @default.
- W2045591069 cites W2104442957 @default.
- W2045591069 cites W2106883076 @default.
- W2045591069 cites W2107863314 @default.
- W2045591069 cites W2108810039 @default.
- W2045591069 cites W2109543726 @default.
- W2045591069 cites W2110931187 @default.
- W2045591069 cites W2111005990 @default.
- W2045591069 cites W2119037301 @default.
- W2045591069 cites W2122677203 @default.
- W2045591069 cites W2125738795 @default.
- W2045591069 cites W2131347613 @default.
- W2045591069 cites W2131538869 @default.
- W2045591069 cites W2131602976 @default.
- W2045591069 cites W2132057054 @default.
- W2045591069 cites W2133546817 @default.
- W2045591069 cites W2134158462 @default.
- W2045591069 cites W2134259738 @default.
- W2045591069 cites W2134650116 @default.
- W2045591069 cites W2134678323 @default.
- W2045591069 cites W2137393500 @default.
- W2045591069 cites W2137710788 @default.
- W2045591069 cites W2137773292 @default.
- W2045591069 cites W2138978095 @default.
- W2045591069 cites W2140167338 @default.
- W2045591069 cites W2141917558 @default.
- W2045591069 cites W2144154516 @default.
- W2045591069 cites W2148626253 @default.
- W2045591069 cites W2150365226 @default.
- W2045591069 cites W2153573637 @default.
- W2045591069 cites W2154040364 @default.
- W2045591069 cites W2155980739 @default.
- W2045591069 cites W2158294001 @default.
- W2045591069 cites W2161085054 @default.
- W2045591069 cites W2161880088 @default.