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- W2045591523 endingPage "320" @default.
- W2045591523 startingPage "311" @default.
- W2045591523 abstract "Primary aldosteronism (PA) encompasses a broad, heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most common form of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension. Despite significant progress in the diagnosis and management of PA, until recently the molecular mechanisms leading to inappropriate aldosterone production were largely unknown. The introduction of next-generation sequencing has had a profound impact on the field of human genetics and has given new insight in the molecular determinants that lead to both sporadic and familial forms of PA. Here we review the recent progress toward understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA." @default.
- W2045591523 created "2016-06-24" @default.
- W2045591523 creator A5004009107 @default.
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- W2045591523 creator A5023647519 @default.
- W2045591523 creator A5058757369 @default.
- W2045591523 creator A5085226848 @default.
- W2045591523 date "2015-01-01" @default.
- W2045591523 modified "2023-10-16" @default.
- W2045591523 title "Understanding primary aldosteronism: impact of next generation sequencing and expression profiling" @default.
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