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• W2045591736 abstract "<i>Introduction:</i> Diabetes mellitus (DM) during pregnancy is associated with an increased risk for poor reproduction and a high rate of congenital malformations. The gerbil <i>Psammomys obesus</i> is a unique model for nutritionally induced Type 2 DM (T2DM) that enabled us to study the outcome of uncontrolled T2DM during pregnancy. <i>Methods:</i> Female <i>Psammomys</i> on low-energy (LE) or high energy (HE) diet were studied. The blood glucose levels and weights of pregnant animals were determined. The offspring from the different groups were followed-up to weaning. <i>Results:</i> Most of the HE-diet animals were diabetic (77%). There were no differences in the pregnancy rates in animals on both diets (32.7% in HE vs. 38.3% in LE). Pregnancy of the HE-diet group was longer than the LE-diet group (26.7 vs. 26.1 days), and litter average was reduced (2.7 vs. 3.0). At birth, the offspring of the HE-diet dams weighed less (5.2 vs. 7.2 g) and had smaller crown rump length (4.0 vs. 4.6 cm) These offspring also presented a 1–3 days delay in neuro-developmental parameters (first turn over, hair appearance, eye-opening and response to noise). However, from the fourth week of life they became diabetic, and from the third week they weighed more than the LE offspring. <i>Conclusion:</i> HE-diet caused diabetes, maternal complications and altered reproduction in <i>Psammomys</i> animals. The offspring of diabetic <i>Psammomys</i> presented birth weight and length changes as well as developmental delay." @default.
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• W2045591736 date "2006-01-01" @default.
• W2045591736 modified "2023-09-26" @default.
• W2045591736 title "Pregnancy Outcome in the <i>Psammomys obesus</i> Gerbil on Low- and High-Energy Diets" @default.
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• W2045591736 doi "https://doi.org/10.1159/000091913" @default.
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