FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045593876> ?p ?o ?g. }

• W2045593876 endingPage "882" @default.
• W2045593876 startingPage "873" @default.
• W2045593876 abstract "A recent genome-wide association study identified the FUT2 secretor status and genotype defined by the single-nucleotide polymorphism rs601338 as potential genetic risk factor in primary sclerosing cholangitis (PSC), which significantly influences biliary bacterial composition.To determine the impact of the rs601338-FUT2 genotype on frequency of biliary infections, development of dominant stenosis and liver-transplantation-free survival in patients with PSC.Cohort study of 215 patients with PSC treated at our tertiary care centre with respect to their rs601338-FUT2 genotype. Results of endoscopic retrograde cholangiography and bile culture were analysed; 639 biliary samples were obtained, cultured and subjected to microbial analysis. Clinical and laboratory data were analysed using chart reviews.For the rs601338-FUT2 genotype, 69 patients (32.1%) were found to be wildtype (GG), 97 (45.1%) patients were heterozygous (AG) and 49 patients (22.8%) were homozygous-mutated (AA). In addition to alterations in the bacterial pattern, especially in heterozygous carriers, patients with mutated alleles had a marked increase in the frequency of biliary Candida infections (P = 0.025). Further, patients with mutated alleles showed an increased frequency of episodes of cholangitis (P = 0.0025), development of dominant stenosis (P < 0.002) and a reduced actuarial transplantation-free survival (P = 0.044). Levels of biliary Ca19-9 were significantly elevated in the homozygous-mutated patients.The rs601338-FUT2 genotype is strongly associated with episodes of cholangitis, fungobilia and the incidence of dominant stenosis, which are three clinical hallmarks of PSC; FUT2 is thus an important genetic risk factor for host-microbial diversity and disease progression in PSC." @default.
• W2045593876 created "2016-06-24" @default.
• W2045593876 creator A5002371143 @default.
• W2045593876 creator A5004326415 @default.
• W2045593876 creator A5006647200 @default.
• W2045593876 creator A5006948160 @default.
• W2045593876 creator A5014972899 @default.
• W2045593876 creator A5046606721 @default.
• W2045593876 creator A5057411583 @default.
• W2045593876 creator A5072719414 @default.
• W2045593876 creator A5077076234 @default.
• W2045593876 creator A5081978650 @default.
• W2045593876 date "2014-02-24" @default.
• W2045593876 modified "2023-09-27" @default.
• W2045593876 title "<i>Fut2</i>genotype is a risk factor for dominant stenosis and biliary candida infections in primary sclerosing cholangitis" @default.
• W2045593876 cites W1874022447 @default.
• W2045593876 cites W1971108757 @default.
• W2045593876 cites W1973957643 @default.
• W2045593876 cites W1975465158 @default.
• W2045593876 cites W1999885934 @default.
• W2045593876 cites W2003122301 @default.
• W2045593876 cites W2012533631 @default.
• W2045593876 cites W2012606594 @default.
• W2045593876 cites W2015627863 @default.
• W2045593876 cites W2028005970 @default.
• W2045593876 cites W2032121837 @default.
• W2045593876 cites W2041092006 @default.
• W2045593876 cites W2046610055 @default.
• W2045593876 cites W2055741797 @default.
• W2045593876 cites W2057613283 @default.
• W2045593876 cites W2060421836 @default.
• W2045593876 cites W2068115215 @default.
• W2045593876 cites W2077527235 @default.
• W2045593876 cites W2080724228 @default.
• W2045593876 cites W2085555653 @default.
• W2045593876 cites W2086465256 @default.
• W2045593876 cites W2089069196 @default.
• W2045593876 cites W2102495280 @default.
• W2045593876 cites W2104956723 @default.
• W2045593876 cites W2106046715 @default.
• W2045593876 cites W2108329405 @default.
• W2045593876 cites W2109585993 @default.
• W2045593876 cites W2125054439 @default.
• W2045593876 cites W2130536159 @default.
• W2045593876 cites W2131039285 @default.
• W2045593876 cites W2132000871 @default.
• W2045593876 cites W2149726658 @default.
• W2045593876 cites W2167700091 @default.
• W2045593876 cites W3140593116 @default.
• W2045593876 cites W5172287 @default.
• W2045593876 doi "https://doi.org/10.1111/apt.12663" @default.
• W2045593876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24612312" @default.
• W2045593876 hasPublicationYear "2014" @default.
• W2045593876 type Work @default.
• W2045593876 sameAs 2045593876 @default.
• W2045593876 citedByCount "27" @default.
• W2045593876 countsByYear W20455938762014 @default.
• W2045593876 countsByYear W20455938762015 @default.
• W2045593876 countsByYear W20455938762016 @default.
• W2045593876 countsByYear W20455938762017 @default.
• W2045593876 countsByYear W20455938762018 @default.
• W2045593876 countsByYear W20455938762020 @default.
• W2045593876 countsByYear W20455938762021 @default.
• W2045593876 countsByYear W20455938762022 @default.
• W2045593876 countsByYear W20455938762023 @default.
• W2045593876 crossrefType "journal-article" @default.
• W2045593876 hasAuthorship W2045593876A5002371143 @default.
• W2045593876 hasAuthorship W2045593876A5004326415 @default.
• W2045593876 hasAuthorship W2045593876A5006647200 @default.
• W2045593876 hasAuthorship W2045593876A5006948160 @default.
• W2045593876 hasAuthorship W2045593876A5014972899 @default.
• W2045593876 hasAuthorship W2045593876A5046606721 @default.
• W2045593876 hasAuthorship W2045593876A5057411583 @default.
• W2045593876 hasAuthorship W2045593876A5072719414 @default.
• W2045593876 hasAuthorship W2045593876A5077076234 @default.
• W2045593876 hasAuthorship W2045593876A5081978650 @default.
• W2045593876 hasBestOaLocation W20455938761 @default.
• W2045593876 hasConcept C104317684 @default.
• W2045593876 hasConcept C126322002 @default.
• W2045593876 hasConcept C135763542 @default.
• W2045593876 hasConcept C180754005 @default.
• W2045593876 hasConcept C2777148285 @default.
• W2045593876 hasConcept C2777683338 @default.
• W2045593876 hasConcept C2777687345 @default.
• W2045593876 hasConcept C2779134260 @default.
• W2045593876 hasConcept C2779609443 @default.
• W2045593876 hasConcept C2780615123 @default.
• W2045593876 hasConcept C2911091166 @default.
• W2045593876 hasConcept C50440223 @default.
• W2045593876 hasConcept C54355233 @default.
• W2045593876 hasConcept C71924100 @default.
• W2045593876 hasConcept C86803240 @default.
• W2045593876 hasConcept C90924648 @default.
• W2045593876 hasConceptScore W2045593876C104317684 @default.
• W2045593876 hasConceptScore W2045593876C126322002 @default.
• W2045593876 hasConceptScore W2045593876C135763542 @default.
• W2045593876 hasConceptScore W2045593876C180754005 @default.
• W2045593876 hasConceptScore W2045593876C2777148285 @default.

• next