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- W2045596582 abstract "An organopalladium complex containing ortho-metalated (S)-(1-(dimethylamino)ethyl)naphthalene as the chiral auxiliary has been used to promote the asymmetric hydrophosphination reactions between diphenylphosphine and (E)- or (Z)-diphenyl-1-propenylphosphine in high regio- and stereoselectivities under mild conditions. Hydrophosphination of (Z)-diphenyl-1-propenylphosphine with diphenylphosphine gave (S)-(-)-prophos as the major product. Using the same chiral metal template, the corresponding hydrophosphination reaction with (E)-diphenyl-1-propenylphosphine gave (R)-(+)-prophos predominantly. The hydrophosphination reactions generated the asymmetric diphosphines as bidentate chelates on the chiral naphthylamine palladium templates. The template products obtained undergo cis-trans isomerization in solution to form an equilibrium mixture of regioisomers. X-ray analysis of the major template products obtained from the hydrophosphination of (Z)-diphenyl-1-propenylphosphine reveals that the two regioisomers are cocrystallized in a 1:1 ratio. The naphthylamine auxiliary could be removed chemoselectively from the template products by treatment with concentrated hydrochloric acid to form the corresponding optically pure neutral complexes [(R)- or (S)-(prophos)PdCl(2)]. Subsequently, the (R)- and (S)-dichloro complexes undergo ligand displacement with aqueous cyanide to generate the corresponding optically pure diphosphine ligands in high yields. Mechanistic pathways explaining the stereoselectivity of the chiral organopalladium template promoted hydrophosphination reactions are also proposed." @default.
- W2045596582 created "2016-06-24" @default.
- W2045596582 creator A5009728774 @default.
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- W2045596582 creator A5038507186 @default.
- W2045596582 creator A5073696111 @default.
- W2045596582 date "2004-11-11" @default.
- W2045596582 modified "2023-10-12" @default.
- W2045596582 title "Chiral Palladium Template Promoted Asymmetric Hydrophosphination Reaction between Diphenylphosphine and Vinylphosphines" @default.
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- W2045596582 doi "https://doi.org/10.1021/ic040091r" @default.
- W2045596582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15578850" @default.
- W2045596582 hasPublicationYear "2004" @default.
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