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• W2045601403 abstract "An investigation of the metabolism of [1,2-3H]-progesterone by human proliferative and secretory phase uterine tissue and the subcellular localization and metabolism of progesterone showed that in the endometrium and the myometrium progesterone was mainly converted to 5α-pregnane-3,20-dione and 20α-hydroxy-4-pregnen-3-one. Smaller quantities of 20α-hydroxy-5α-pregnan-3-one, 6β-hydroxy-progesterone and unidentified polar metabolites were also formed. Qualitatively this metabolism did not appear to vary significantly in the human endometrium and myometrium. However, quantitative variations between the endometrium and myometrium were apparent in both the proliferative and secretory phases of the cycle. Conversion of progesterone to 5α-pregnane-3, 20-dione was higher in the endometrium than in the myometrium, while more of 20α-hydroxy-4-pregnen-3-one was formed by the myometrium. More 20α-hydroxy-4-pregnen-3-one was formed in the secretory than in the proliferative phase. Localization of progesterone in the subcellular fractions of the endometrium and myometrium showed that progesterone and its metabolites are mainly localised in the cytosol fraction, wherein they bind specifically to receptor protein. The nuclear uptake was considerably lower than that of the cytosol fraction. The subcellular metabolism of progesterone in the individual fractions, in the presence of co-factors, revealed that the conversion of progesterone was higher in the cytosol fraction. The major metabolite formed in the nuclear fraction of endometrium and myometrium was 5α-pregnane-3,20-dione. In the mitochondrial fraction 5α-pregnane-3,20-dione, 20α-hydroxy-5α-pregnan-3-one and some highly polar compounds were formed. 6β-hydroxy-progesterone was formed to a considerable extent by the microsomal and mitochondrial fractions. In the cytosol fractions of both the endometrium and myometrium, 20α-hydroxy-4-pregnen-3-one was the major metabolite with small amounts of 6β-hydroxy-progesterone, 5α-pregnane-3, 20-dione and 20α-hydroxy-5α-pregnan-3-one." @default.
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• W2045601403 date "1976-04-01" @default.
• W2045601403 modified "2023-09-24" @default.
• W2045601403 title "Cellular and subcellular metabolism of progesterone by the human proliferative and secretory phase endometrium and myometrium" @default.
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• W2045601403 doi "https://doi.org/10.1016/0022-4731(76)90127-8" @default.
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