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• W2045604534 abstract "Type 2 diabetes mellitus (DM) and Alzheimer's disease (AD) share epidemiological and biochemical features. Both are characterized by insoluble protein aggregates with a fibrillar conformation – amylin in Type 2 DM pancreatic islets, and Aβ in AD brain. To determine whether amylin shares neurotoxic properties with Aβ, we incubated hippocampal and cortical neurons with Aβ42 and human amylin. Different from non-amyloidogenic rat amylin, both caused a dose-, time- and cell type-specific neurotoxicity supporting the notion of a similar toxic mechanism. Depending on the cell type, this finding is also supported by co-incubation of human amylin and Aβ." @default.
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• W2045604534 date "2008-05-16" @default.
• W2045604534 modified "2023-09-24" @default.
• W2045604534 title "Human but not rat amylin shares neurotoxic properties with Aβ42 in long-term hippocampal and cortical cultures" @default.
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• W2045604534 doi "https://doi.org/10.1016/j.febslet.2008.05.006" @default.
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