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- W2045607564 abstract "Oestrogen can alter neuroendocrine responses to stress but the evidence is conflicting. We examined the effects of a short-term 17beta-oestradiol surge versus a continuous 17beta-oestradiol replacement regime on neuroendocrine cell responses to hypoxia in the ovariectomized rat. Short-term oestradiol replacement significantly increased the number of Fos-positive SON and PVN OT cells and VLM A1 and C1 cells following hypoxia. In contrast, continuous oestradiol replacement significantly decreased the number of hypoxia-induced Fos-positive mPVN, PVN OT and VLM A1 and C1 and NTS C2 cells. We propose that the effects of oestradiol replacement on stress-induced neuroendocrine responses may be dependent on whether oestrogen levels are rising rapidly or remaining constant over a relatively long period." @default.
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- W2045607564 date "2000-07-01" @default.
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- W2045607564 title "Opposite effects of short and continuous oestradiol replacement on CNS responses to hypoxic stress" @default.
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- W2045607564 doi "https://doi.org/10.1097/00001756-200007140-00036" @default.
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